Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

Xanthine oxidoreductase has been implicated in cancer. Nonetheless, the role played by its two convertible forms, xanthine dehydrogenase (XDH) and oxidase (XO) during tumorigenesis is not understood. Here we produce XDH-stable and XO-locked knock-in (ki) mice to address this question. After tumor tr...

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Detalles Bibliográficos
Autores principales: Kusano, Teruo, Ehirchiou, Driss, Matsumura, Tomohiro, Chobaz, Veronique, Nasi, Sonia, Castelblanco, Mariela, So, Alexander, Lavanchy, Christine, Acha-Orbea, Hans, Nishino, Takeshi, Okamoto, Ken, Busso, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817904/
https://www.ncbi.nlm.nih.gov/pubmed/31659168
http://dx.doi.org/10.1038/s41467-019-12565-z

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