Cargando…

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Gliomas are primary, diffusely infiltrating brain tumors. Microglia are innate immune cells in the CNS and make up a substantial portion of the tumor mass. Glioma cells shape their microenvironment, communicating with and reprogramming surrounding cells, resulting in enhanced angiogenesis, immune su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abels, Erik R., Maas, Sybren L.N., Nieland, Lisa, Wei, Zhiyun, Cheah, Pike See, Tai, Eric, Kolsteeg, Christy-Joy, Dusoswa, Sophie A., Ting, David T., Hickman, Suzanne, El Khoury, Joseph, Krichevsky, Anna M., Broekman, Marike L.D., Breakefield, Xandra O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817978/ https://www.ncbi.nlm.nih.gov/pubmed/31533034 http://dx.doi.org/10.1016/j.celrep.2019.08.036

Ejemplares similares

CRISPR-Cas knockout of miR21 reduces glioma growth
por: Nieland, Lisa, et al.
Publicado: (2022)

Comparative Analysis Identifies Similarities between the Human and Murine Microglial Sensomes
por: Abels, Erik R., et al.
Publicado: (2021)

GlioM&M: Web-based tool for studying circulating and infiltrating monocytes and macrophages in glioma
por: Abels, Erik R., et al.
Publicado: (2020)

Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression
por: van Solinge, Thomas S., et al.
Publicado: (2020)

Glioblastoma hijacks microglial gene expression to support tumor growth
por: Maas, Sybren L. N., et al.
Publicado: (2020)

AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice
por: Prabhakar, Shilpa, et al.
Publicado: (2021)

Illuminating cellular and extracellular vesicle-mediated communication via a split-Nanoluc reporter in vitro and in vivo
por: van Solinge, Thomas S., et al.
Publicado: (2023)

Engineered EVs designed to target diseases of the CNS
por: Nieland, Lisa, et al.
Publicado: (2023)

Heparin in malignant glioma: review of preclinical studies and clinical results
por: Schnoor, Rosalie, et al.
Publicado: (2015)

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing
por: Maas, Sybren L. N., et al.
Publicado: (2014)

Living Proof of Activity of Extracellular Vesicles in the Central Nervous System
por: Mahjoum, Shadi, et al.
Publicado: (2021)

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics
por: Maas, Sybren L.N., et al.
Publicado: (2015)

Basic science in neurosurgery
por: van Solinge, Thomas S., et al.
Publicado: (2023)

Emerging nanomedical strategies for direct targeting of pediatric and adult diffuse gliomas
por: Kolsteeg, Christy, et al.
Publicado: (2022)

Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles
por: Zaborowski, Mikołaj Piotr, et al.
Publicado: (2019)

Heparin interferes with the uptake of liposomes in glioma
por: van Solinge, Thomas S., et al.
Publicado: (2023)

Co-cultures of Glioma Stem Cells and Primary Neurons, Astrocytes, Microglia, and Endothelial Cells for Investigation of Intercellular Communication in the Brain
por: Wei, Zhiyun, et al.
Publicado: (2019)

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
por: Wei, Zhiyun, et al.
Publicado: (2017)

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1
por: Prabhakar, Shilpa, et al.
Publicado: (2019)

Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers
por: Skog, Johan, et al.
Publicado: (2008)

Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies
por: Lai, Charles Pin-Kuang, et al.
Publicado: (2012)

In vivo tomographic imaging of red-shifted fluorescent proteins
por: Deliolanis, Nikolaos C., et al.
Publicado: (2011)

miRNA signature of schwannomas: Possible role(s) of “tumor suppressor” miRNAs in benign tumors
por: Erkan, Erdogan Pekcan, et al.
Publicado: (2011)

How to reprogram microglia toward beneficial functions
por: Fumagalli, Marta, et al.
Publicado: (2018)

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function
por: Cruz, Lilian, et al.
Publicado: (2020)

Nanocarrier-based drug combination therapy for glioblastoma
por: Zhao, Mengnan, et al.
Publicado: (2020)

Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2
por: Prabhakar, Shilpa, et al.
Publicado: (2022)

SOX3 expression in the glial system of the developing and adult mouse cerebellum
por: Cheah, Pike-See, et al.
Publicado: (2015)

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response
por: Lauro, Clotilde, et al.
Publicado: (2020)

Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin
por: Cheah, Pike-See, et al.
Publicado: (2021)

Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis
por: Pike, Lisa S., et al.
Publicado: (2011)

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles
por: Zaborowski, Mikołaj Piotr, et al.
Publicado: (2019)

Propofol inhibits neuroinflammation and metabolic reprogramming in microglia in vitro and in vivo
por: Guan, Shuyuan, et al.
Publicado: (2023)

Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism
por: Zeng, Ailiang, et al.
Publicado: (2020)

A Highly Sensitive Assay for Monitoring the Secretory Pathway and ER Stress
por: Badr, Christian E., et al.
Publicado: (2007)

Isolation, cultivation and immunostaining of single myofibers: An improved approach to study the behavior of satellite cells
por: Lim, Chai Ling, et al.
Publicado: (2018)

Practice-Pattern Variation in Sedation of Neurotrauma Patients in the Intensive Care Unit: An International Survey
por: Dolmans, Rianne G.F., et al.
Publicado: (2023)

RNA delivery by extracellular vesicles in mammalian cells and its applications
por: O’Brien, Killian, et al.
Publicado: (2020)

Uptake, functionality, and re-release of extracellular vesicle-encapsulated cargo
por: O’Brien, Killian, et al.
Publicado: (2022)

REST Targets JAK–STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells
por: Huang, Tan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_skk9hjm6bc1uf2ko6cqc643tl4