POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas

BACKGROUND: Mutations in the POT1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas (CAS). However, the link between long telomeres and tumorigenesis is poorly understood. METHODS AND RESULTS: Here, we have studied the somatic landscape of 3 different angiosa...

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Detalles Bibliográficos
Autores principales: Calvete, Oriol, Garcia‐Pavia, Pablo, Domínguez, Fernando, Mosteiro, Lluc, Pérez‐Cabornero, Lucía, Cantalapiedra, Diego, Zorio, Esther, Ramón y Cajal, Teresa, Crespo‐Leiro, Maria G., Teulé, Álex, Lázaro, Conxi, Morente, Manuel M., Urioste, Miguel, Benitez, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818007/
https://www.ncbi.nlm.nih.gov/pubmed/31510873
http://dx.doi.org/10.1161/JAHA.119.012875

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