Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt‐Sensitive Hypertension

BACKGROUND: Elevated levels of an endogenous Na/K‐ATPase inhibitor marinobufagenin accompany salt‐sensitive hypertension and are implicated in cardiac fibrosis. Immunoneutralization of marinobufagenin reduces blood pressure in Dahl salt‐sensitive (Dahl‐S) rats. The effect of the anti‐marinobufagenin...

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Detalles Bibliográficos
Autores principales: Zhang, Yongqing, Wei, Wen, Shilova, Victoria, Petrashevskaya, Natalia N., Zernetkina, Valentina I., Grigorova, Yulia N., Marshall, Courtney A., Fenner, Rachel C., Lehrmann, Elin, Wood, William H., Becker, Kevin G., Lakatta, Edward G., Bagrov, Alexei Y., Fedorova, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818028/
https://www.ncbi.nlm.nih.gov/pubmed/31576777
http://dx.doi.org/10.1161/JAHA.119.012138

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