Cargando…

Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample

Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little wor...

Descripción completa

Detalles Bibliográficos
Autores principales: Khanthiyong, Bupachad, Thanoi, Samur, Reynolds, Gavin P., Nudmamud-Thanoi, Sutisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818203/
https://www.ncbi.nlm.nih.gov/pubmed/31673237
http://dx.doi.org/10.7150/ijms.35789
_version_ 1783463578808877056
author Khanthiyong, Bupachad
Thanoi, Samur
Reynolds, Gavin P.
Nudmamud-Thanoi, Sutisa
author_facet Khanthiyong, Bupachad
Thanoi, Samur
Reynolds, Gavin P.
Nudmamud-Thanoi, Sutisa
author_sort Khanthiyong, Bupachad
collection PubMed
description Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little work has investigated this in the Thai population and the relationship of age and education with this association remains unclear. Therefore, this study was designed to investigate the association of this polymorphism of the COMT gene with executive cognitive brain function in healthy subjects and the relationship with age and education. The Wisconsin Card Sorting Test (WCST) was performed to assess executive function in 254 healthy Thai subjects (aged 20-72 years). The results showed a significant association of rs4680 with executive function, in which Val/Met heterozygotes demonstrated better cognitive set shifting performance. Moreover, Met allele carriers showed a significantly stronger effect in the categories completed score than did Val homozygotes. Furthermore, age and education also showed a significant association with COMT genotype and WCST. These results revealed that executive cognitive function is associated with COMT genotype and influenced by age and/or education level in a Thai sample.
format Online
Article
Text
id pubmed-6818203
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-68182032019-10-31 Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample Khanthiyong, Bupachad Thanoi, Samur Reynolds, Gavin P. Nudmamud-Thanoi, Sutisa Int J Med Sci Research Paper Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little work has investigated this in the Thai population and the relationship of age and education with this association remains unclear. Therefore, this study was designed to investigate the association of this polymorphism of the COMT gene with executive cognitive brain function in healthy subjects and the relationship with age and education. The Wisconsin Card Sorting Test (WCST) was performed to assess executive function in 254 healthy Thai subjects (aged 20-72 years). The results showed a significant association of rs4680 with executive function, in which Val/Met heterozygotes demonstrated better cognitive set shifting performance. Moreover, Met allele carriers showed a significantly stronger effect in the categories completed score than did Val homozygotes. Furthermore, age and education also showed a significant association with COMT genotype and WCST. These results revealed that executive cognitive function is associated with COMT genotype and influenced by age and/or education level in a Thai sample. Ivyspring International Publisher 2019-09-20 /pmc/articles/PMC6818203/ /pubmed/31673237 http://dx.doi.org/10.7150/ijms.35789 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Khanthiyong, Bupachad
Thanoi, Samur
Reynolds, Gavin P.
Nudmamud-Thanoi, Sutisa
Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title_full Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title_fullStr Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title_full_unstemmed Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title_short Association study of the functional Catechol-O-Methyltranferase (COMT) Val(158)Met polymorphism on executive cognitive function in a Thai sample
title_sort association study of the functional catechol-o-methyltranferase (comt) val(158)met polymorphism on executive cognitive function in a thai sample
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818203/
https://www.ncbi.nlm.nih.gov/pubmed/31673237
http://dx.doi.org/10.7150/ijms.35789
work_keys_str_mv AT khanthiyongbupachad associationstudyofthefunctionalcatecholomethyltranferasecomtval158metpolymorphismonexecutivecognitivefunctioninathaisample
AT thanoisamur associationstudyofthefunctionalcatecholomethyltranferasecomtval158metpolymorphismonexecutivecognitivefunctioninathaisample
AT reynoldsgavinp associationstudyofthefunctionalcatecholomethyltranferasecomtval158metpolymorphismonexecutivecognitivefunctioninathaisample
AT nudmamudthanoisutisa associationstudyofthefunctionalcatecholomethyltranferasecomtval158metpolymorphismonexecutivecognitivefunctioninathaisample