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Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics

Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579...

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Autores principales: Lin, Chia-Yen, Wang, Shian-Shiang, Yang, Cheng-Kuang, Li, Jian-Ri, Chen, Chuan-Shu, Hung, Sheng-Chun, Chiu, Kun-Yuan, Cheng, Chen-Li, Ou, Yen-Chuan, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818208/
https://www.ncbi.nlm.nih.gov/pubmed/31673232
http://dx.doi.org/10.7150/ijms.38080
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author Lin, Chia-Yen
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
author_facet Lin, Chia-Yen
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
author_sort Lin, Chia-Yen
collection PubMed
description Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579 prostate cancer patients who underwent robot-assisted radical prostatectomy and 579 healthy controls were included. The frequency of the allele del of rs145204276 were compared between the patients and the controls to evaluate the impact of tumor susceptibility and the correlation of clinicopathological variables. The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins. In the subgroup analysis of age, more significant risk reduction effects were noted over lymph node metastasis disease (OR=0.426, p=0.032) and lymphovascular invasion (OR=0.521, p=0.025). In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis.
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spelling pubmed-68182082019-10-31 Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics Lin, Chia-Yen Wang, Shian-Shiang Yang, Cheng-Kuang Li, Jian-Ri Chen, Chuan-Shu Hung, Sheng-Chun Chiu, Kun-Yuan Cheng, Chen-Li Ou, Yen-Chuan Yang, Shun-Fa Int J Med Sci Research Paper Down-regulation of Growth arrest-specific 5 (GAS5) is correlated with enhanced cell proliferation and poorer prognosis of prostate cancer. We aimed to investigate the effect of variant rs145204276 of GAS5 on the prostate cancer susceptibility and clinicopathologic characteristics. In this study, 579 prostate cancer patients who underwent robot-assisted radical prostatectomy and 579 healthy controls were included. The frequency of the allele del of rs145204276 were compared between the patients and the controls to evaluate the impact of tumor susceptibility and the correlation of clinicopathological variables. The results shown that patients who carries genotype ins/del or del/del at SNP rs145204276 showed decreased risk of pathological lymph node metastasis disease (OR=0.545, p=0.043) and risk of seminal vesicle invasion (OR=0.632, p=0.022) comparing to with genotype ins/ins. In the subgroup analysis of age, more significant risk reduction effects were noted over lymph node metastasis disease (OR=0.426, p=0.032) and lymphovascular invasion (OR=0.521, p=0.025). In conclusion, the rs145204276 polymorphic genotype of GAS5 can predict the risk of lymph node metastasis. This is the first study to report the correlation between GAS5 gene polymorphism and prostate cancer prognosis. Ivyspring International Publisher 2019-09-20 /pmc/articles/PMC6818208/ /pubmed/31673232 http://dx.doi.org/10.7150/ijms.38080 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Lin, Chia-Yen
Wang, Shian-Shiang
Yang, Cheng-Kuang
Li, Jian-Ri
Chen, Chuan-Shu
Hung, Sheng-Chun
Chiu, Kun-Yuan
Cheng, Chen-Li
Ou, Yen-Chuan
Yang, Shun-Fa
Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title_full Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title_fullStr Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title_full_unstemmed Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title_short Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
title_sort impact of gas5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818208/
https://www.ncbi.nlm.nih.gov/pubmed/31673232
http://dx.doi.org/10.7150/ijms.38080
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