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Phosphofructokinases Axis Controls Glucose-Dependent mTORC1 Activation Driven by E2F1

Cancer cells rely on mTORC1 activity to coordinate mitogenic signaling with nutrients availability for growth. Based on the metabolic function of E2F1, we hypothesize that glucose catabolism driven by E2F1 could participate on mTORC1 activation. Here, we demonstrate that glucose potentiates E2F1-ind...

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Detalles Bibliográficos
Autores principales:	Almacellas, Eugènia, Pelletier, Joffrey, Manzano, Anna, Gentilella, Antonio, Ambrosio, Santiago, Mauvezin, Caroline, Tauler, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818336/ https://www.ncbi.nlm.nih.gov/pubmed/31627130 http://dx.doi.org/10.1016/j.isci.2019.09.040

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