Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly

The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and bacteria. The obligate intracellular bacterial pathog...

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Detalles Bibliográficos
Autores principales: Slade, Jessica A., Brockett, Mary, Singh, Raghuveer, Liechti, George W., Maurelli, Anthony T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818789/
https://www.ncbi.nlm.nih.gov/pubmed/31622442
http://dx.doi.org/10.1371/journal.ppat.1008078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818789/
https://www.ncbi.nlm.nih.gov/pubmed/31622442
http://dx.doi.org/10.1371/journal.ppat.1008078

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