An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment. We demonstrated that exposure to Mtb directs primary human CD34(+) cells to differentiate into monocytes/macrophages. In vitro m...

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Detalles Bibliográficos
Autores principales: Delgobo, Murilo, Mendes, Daniel AGB, Kozlova, Edgar, Rocha, Edroaldo Lummertz, Rodrigues-Luiz, Gabriela F, Mascarin, Lucas, Dias, Greicy, Patrício, Daniel O, Dierckx, Tim, Bicca, Maíra A, Bretton, Gaëlle, Tenório de Menezes, Yonne Karoline, Starick, Márick R, Rovaris, Darcita, Del Moral, Joanita, Mansur, Daniel S, Van Weyenbergh, Johan, Báfica, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819084/
https://www.ncbi.nlm.nih.gov/pubmed/31637998
http://dx.doi.org/10.7554/eLife.47013

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