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Physiological significance of ghrelin in the cardiovascular system

Ghrelin, a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor. It participates in the regulation of diverse processes, including energy balance and body weight maintenance, and appears to be beneficial for the treatment...

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Detalles Bibliográficos
Autores principales: TOKUDOME, Takeshi, KANGAWA, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819151/
https://www.ncbi.nlm.nih.gov/pubmed/31611501
http://dx.doi.org/10.2183/pjab.95.032
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author TOKUDOME, Takeshi
KANGAWA, Kenji
author_facet TOKUDOME, Takeshi
KANGAWA, Kenji
author_sort TOKUDOME, Takeshi
collection PubMed
description Ghrelin, a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor. It participates in the regulation of diverse processes, including energy balance and body weight maintenance, and appears to be beneficial for the treatment of cardiovascular diseases. In animal models of chronic heart failure, ghrelin improves cardiac function and remodeling; these findings have been recapitulated in human patients. In other animal models, ghrelin effectively diminishes pulmonary hypertension. Moreover, ghrelin administration early after myocardial infarction decreased the frequency of fatal arrhythmia and improved survival rate. In ghrelin-deficient mice, endogenous ghrelin protects against fatal arrhythmia and promotes remodeling after myocardial infarction. Although the mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, its beneficial effects appear to be mediated through regulation of the autonomic nervous system. Ghrelin is a promising therapeutic agent for cardiac diseases.
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spelling pubmed-68191512019-11-04 Physiological significance of ghrelin in the cardiovascular system TOKUDOME, Takeshi KANGAWA, Kenji Proc Jpn Acad Ser B Phys Biol Sci Review Ghrelin, a growth hormone-releasing peptide first discovered in rat stomach in 1999, is a ligand for the growth hormone secretagogue receptor. It participates in the regulation of diverse processes, including energy balance and body weight maintenance, and appears to be beneficial for the treatment of cardiovascular diseases. In animal models of chronic heart failure, ghrelin improves cardiac function and remodeling; these findings have been recapitulated in human patients. In other animal models, ghrelin effectively diminishes pulmonary hypertension. Moreover, ghrelin administration early after myocardial infarction decreased the frequency of fatal arrhythmia and improved survival rate. In ghrelin-deficient mice, endogenous ghrelin protects against fatal arrhythmia and promotes remodeling after myocardial infarction. Although the mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, its beneficial effects appear to be mediated through regulation of the autonomic nervous system. Ghrelin is a promising therapeutic agent for cardiac diseases. The Japan Academy 2019-10-11 /pmc/articles/PMC6819151/ /pubmed/31611501 http://dx.doi.org/10.2183/pjab.95.032 Text en © 2019 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
TOKUDOME, Takeshi
KANGAWA, Kenji
Physiological significance of ghrelin in the cardiovascular system
title Physiological significance of ghrelin in the cardiovascular system
title_full Physiological significance of ghrelin in the cardiovascular system
title_fullStr Physiological significance of ghrelin in the cardiovascular system
title_full_unstemmed Physiological significance of ghrelin in the cardiovascular system
title_short Physiological significance of ghrelin in the cardiovascular system
title_sort physiological significance of ghrelin in the cardiovascular system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819151/
https://www.ncbi.nlm.nih.gov/pubmed/31611501
http://dx.doi.org/10.2183/pjab.95.032
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