The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinomas (HNSCCs) are closely linked with immunosuppression, accompanied by complex immune cell functional activities. The abnormal competition between costimulatory and coinhibitory signal molecules plays an important role in the malignant progression of HNSCC. This re...

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Autores principales: Liao, Peng, Wang, Haofan, Tang, Ya-ling, Tang, Ya-Jie, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819372/
https://www.ncbi.nlm.nih.gov/pubmed/31708918
http://dx.doi.org/10.3389/fimmu.2019.02457
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author Liao, Peng
Wang, Haofan
Tang, Ya-ling
Tang, Ya-Jie
Liang, Xin-hua
author_facet Liao, Peng
Wang, Haofan
Tang, Ya-ling
Tang, Ya-Jie
Liang, Xin-hua
author_sort Liao, Peng
collection PubMed
description Head and neck squamous cell carcinomas (HNSCCs) are closely linked with immunosuppression, accompanied by complex immune cell functional activities. The abnormal competition between costimulatory and coinhibitory signal molecules plays an important role in the malignant progression of HNSCC. This review will summarize the features of costimulatory molecules (including CD137, OX40 as well as CD40) and coinhibitory molecules (including CTLA-4, PD-1, LAG3, and TIM3), analyze the underlying mechanism behind these molecules' regulation of the progression of HNSCC, and introduce the clinic application. Vaccines, such as those targeting STING while working synergistically with monoclonal antibodies, are also discussed. A deep understanding of the tumor immune landscape will help find new and improved tumor immunotherapy for HNSCC.
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spelling pubmed-68193722019-11-08 The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma Liao, Peng Wang, Haofan Tang, Ya-ling Tang, Ya-Jie Liang, Xin-hua Front Immunol Immunology Head and neck squamous cell carcinomas (HNSCCs) are closely linked with immunosuppression, accompanied by complex immune cell functional activities. The abnormal competition between costimulatory and coinhibitory signal molecules plays an important role in the malignant progression of HNSCC. This review will summarize the features of costimulatory molecules (including CD137, OX40 as well as CD40) and coinhibitory molecules (including CTLA-4, PD-1, LAG3, and TIM3), analyze the underlying mechanism behind these molecules' regulation of the progression of HNSCC, and introduce the clinic application. Vaccines, such as those targeting STING while working synergistically with monoclonal antibodies, are also discussed. A deep understanding of the tumor immune landscape will help find new and improved tumor immunotherapy for HNSCC. Frontiers Media S.A. 2019-10-23 /pmc/articles/PMC6819372/ /pubmed/31708918 http://dx.doi.org/10.3389/fimmu.2019.02457 Text en Copyright © 2019 Liao, Wang, Tang, Tang and Liang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liao, Peng
Wang, Haofan
Tang, Ya-ling
Tang, Ya-Jie
Liang, Xin-hua
The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title_full The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title_fullStr The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title_short The Common Costimulatory and Coinhibitory Signaling Molecules in Head and Neck Squamous Cell Carcinoma
title_sort common costimulatory and coinhibitory signaling molecules in head and neck squamous cell carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819372/
https://www.ncbi.nlm.nih.gov/pubmed/31708918
http://dx.doi.org/10.3389/fimmu.2019.02457
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