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Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia

OBJECTIVE: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. RESULTS: Using a cross-sectional study, blood samples were collected f...

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Autores principales: Shibabaw, Tewodros, Dessie, Gashaw, Molla, Meseret Derbew, Zerihun, Muluken Fekadie, Ayelign, Birhanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819379/
https://www.ncbi.nlm.nih.gov/pubmed/31665087
http://dx.doi.org/10.1186/s13104-019-4742-x
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author Shibabaw, Tewodros
Dessie, Gashaw
Molla, Meseret Derbew
Zerihun, Muluken Fekadie
Ayelign, Birhanu
author_facet Shibabaw, Tewodros
Dessie, Gashaw
Molla, Meseret Derbew
Zerihun, Muluken Fekadie
Ayelign, Birhanu
author_sort Shibabaw, Tewodros
collection PubMed
description OBJECTIVE: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. RESULTS: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer’s kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls.
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spelling pubmed-68193792019-10-31 Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia Shibabaw, Tewodros Dessie, Gashaw Molla, Meseret Derbew Zerihun, Muluken Fekadie Ayelign, Birhanu BMC Res Notes Research Note OBJECTIVE: This study aimed to assess the level of aspartate aminotransaminase (AST), alanine aminotransaminase (ALT) and gamma-glutamyltransferase (GGT), and their association with type 2 diabetes mellitus in Northwest Ethiopia. RESULTS: Using a cross-sectional study, blood samples were collected from 192 Type 2 diabetes mellitus (T2DM) participants and 192 healthy age and sex-matched volunteers. The study was carried out from May to August 2017. The serum concentration of aspartate aminotransaminase, alanine aminotransaminase, and gamma-glutamyltransferase were measured using A25 Bio-system fully automatic chemistry analyzer and using the manufacturer’s kit of the machine. Liver function test results of T2DM participant were significantly higher than those of the control group, serum ALT (46.06 ± 22. 38 IU/L) and serum AST (42.94 ± 19. 08 IU/L), P < 0.001, while the level of GGT in both study groups was not significantly associated (P = 0.065). In conclusion, the evaluation of liver marker enzymes showed a significant association with Type 2 diabetes participants compared with the controls. BioMed Central 2019-10-29 /pmc/articles/PMC6819379/ /pubmed/31665087 http://dx.doi.org/10.1186/s13104-019-4742-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Shibabaw, Tewodros
Dessie, Gashaw
Molla, Meseret Derbew
Zerihun, Muluken Fekadie
Ayelign, Birhanu
Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title_full Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title_fullStr Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title_full_unstemmed Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title_short Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia
title_sort assessment of liver marker enzymes and its association with type 2 diabetes mellitus in northwest ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819379/
https://www.ncbi.nlm.nih.gov/pubmed/31665087
http://dx.doi.org/10.1186/s13104-019-4742-x
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