Human iPSC banking: barriers and opportunities

The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based drug discovery and toxicity assessment. Over the past 10 years, several initiatives have bee...

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Autores principales: Huang, Ching-Ying, Liu, Chun-Lin, Ting, Chien-Yu, Chiu, Yueh-Ting, Cheng, Yu-Che, Nicholson, Martin W., Hsieh, Patrick C. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819403/
https://www.ncbi.nlm.nih.gov/pubmed/31660969
http://dx.doi.org/10.1186/s12929-019-0578-x
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author Huang, Ching-Ying
Liu, Chun-Lin
Ting, Chien-Yu
Chiu, Yueh-Ting
Cheng, Yu-Che
Nicholson, Martin W.
Hsieh, Patrick C. H.
author_facet Huang, Ching-Ying
Liu, Chun-Lin
Ting, Chien-Yu
Chiu, Yueh-Ting
Cheng, Yu-Che
Nicholson, Martin W.
Hsieh, Patrick C. H.
author_sort Huang, Ching-Ying
collection PubMed
description The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based drug discovery and toxicity assessment. Over the past 10 years, several initiatives have been established that aim to collect and generate a large amount of human iPSCs for scientific research purposes. In this review, we compare the construction and operation strategy of some iPSC banks as well as their ongoing development. We also introduce the technical challenges and offer future perspectives pertaining to the establishment and management of iPSC banks.
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spelling pubmed-68194032019-10-31 Human iPSC banking: barriers and opportunities Huang, Ching-Ying Liu, Chun-Lin Ting, Chien-Yu Chiu, Yueh-Ting Cheng, Yu-Che Nicholson, Martin W. Hsieh, Patrick C. H. J Biomed Sci Review The introduction of induced pluripotent stem cells (iPSCs) has opened up the potential for personalized cell therapies and ushered in new opportunities for regenerative medicine, disease modeling, iPSC-based drug discovery and toxicity assessment. Over the past 10 years, several initiatives have been established that aim to collect and generate a large amount of human iPSCs for scientific research purposes. In this review, we compare the construction and operation strategy of some iPSC banks as well as their ongoing development. We also introduce the technical challenges and offer future perspectives pertaining to the establishment and management of iPSC banks. BioMed Central 2019-10-28 /pmc/articles/PMC6819403/ /pubmed/31660969 http://dx.doi.org/10.1186/s12929-019-0578-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Huang, Ching-Ying
Liu, Chun-Lin
Ting, Chien-Yu
Chiu, Yueh-Ting
Cheng, Yu-Che
Nicholson, Martin W.
Hsieh, Patrick C. H.
Human iPSC banking: barriers and opportunities
title Human iPSC banking: barriers and opportunities
title_full Human iPSC banking: barriers and opportunities
title_fullStr Human iPSC banking: barriers and opportunities
title_full_unstemmed Human iPSC banking: barriers and opportunities
title_short Human iPSC banking: barriers and opportunities
title_sort human ipsc banking: barriers and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819403/
https://www.ncbi.nlm.nih.gov/pubmed/31660969
http://dx.doi.org/10.1186/s12929-019-0578-x
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