GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

BACKGROUND: Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tumor cell survival and chemoresistance. The aim of our stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Cournoyer, Sonia, Addioui, Anissa, Belounis, Assila, Beaunoyer, Mona, Nyalendo, Carine, Le Gall, Roxane, Teira, Pierre, Haddad, Elie, Vassal, Gilles, Sartelet, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819521/
https://www.ncbi.nlm.nih.gov/pubmed/31664947
http://dx.doi.org/10.1186/s12885-019-6195-y

Ejemplares similares

Ejemplares similares