Studying the gut virome in the metagenomic era: challenges and perspectives

The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remai...

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Autores principales: Garmaeva, Sanzhima, Sinha, Trishla, Kurilshikov, Alexander, Fu, Jingyuan, Wijmenga, Cisca, Zhernakova, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819614/
https://www.ncbi.nlm.nih.gov/pubmed/31660953
http://dx.doi.org/10.1186/s12915-019-0704-y
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author Garmaeva, Sanzhima
Sinha, Trishla
Kurilshikov, Alexander
Fu, Jingyuan
Wijmenga, Cisca
Zhernakova, Alexandra
author_facet Garmaeva, Sanzhima
Sinha, Trishla
Kurilshikov, Alexander
Fu, Jingyuan
Wijmenga, Cisca
Zhernakova, Alexandra
author_sort Garmaeva, Sanzhima
collection PubMed
description The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems.
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spelling pubmed-68196142019-10-31 Studying the gut virome in the metagenomic era: challenges and perspectives Garmaeva, Sanzhima Sinha, Trishla Kurilshikov, Alexander Fu, Jingyuan Wijmenga, Cisca Zhernakova, Alexandra BMC Biol Review The human gut harbors a complex ecosystem of microorganisms, including bacteria and viruses. With the rise of next-generation sequencing technologies, we have seen a quantum leap in the study of human-gut-inhabiting bacteria, yet the viruses that infect these bacteria, known as bacteriophages, remain underexplored. In this review, we focus on what is known about the role of bacteriophages in human health and the technical challenges involved in studying the gut virome, of which they are a major component. Lastly, we discuss what can be learned from studies of bacteriophages in other ecosystems. BioMed Central 2019-10-28 /pmc/articles/PMC6819614/ /pubmed/31660953 http://dx.doi.org/10.1186/s12915-019-0704-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Garmaeva, Sanzhima
Sinha, Trishla
Kurilshikov, Alexander
Fu, Jingyuan
Wijmenga, Cisca
Zhernakova, Alexandra
Studying the gut virome in the metagenomic era: challenges and perspectives
title Studying the gut virome in the metagenomic era: challenges and perspectives
title_full Studying the gut virome in the metagenomic era: challenges and perspectives
title_fullStr Studying the gut virome in the metagenomic era: challenges and perspectives
title_full_unstemmed Studying the gut virome in the metagenomic era: challenges and perspectives
title_short Studying the gut virome in the metagenomic era: challenges and perspectives
title_sort studying the gut virome in the metagenomic era: challenges and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819614/
https://www.ncbi.nlm.nih.gov/pubmed/31660953
http://dx.doi.org/10.1186/s12915-019-0704-y
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