Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure

Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect. Such strains represent a source from which antibiotic resistance may reemerge to cause tr...

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Detalles Bibliográficos
Autores principales: Kime, Louise, Randall, Christopher P., Banda, Frank I., Coll, Francesc, Wright, John, Richardson, Joseph, Empel, Joanna, Parkhill, Julian, O’Neill, Alex J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819657/
https://www.ncbi.nlm.nih.gov/pubmed/31662453
http://dx.doi.org/10.1128/mBio.01755-19

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