Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target

E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dU...

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Detalles Bibliográficos
Autores principales: Li, Changyao, Chai, Yan, Song, Hao, Weng, Changjiang, Qi, Jianxun, Sun, Yeping, Gao, George F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819664/
https://www.ncbi.nlm.nih.gov/pubmed/31662460
http://dx.doi.org/10.1128/mBio.02483-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819664/
https://www.ncbi.nlm.nih.gov/pubmed/31662460
http://dx.doi.org/10.1128/mBio.02483-19

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