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Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood
Background: Long non-coding RNAs (lncRNAs) are a group of functional transcripts that are not translated to proteins. Recent investigations have underscored their role in the pathogenesis of neurodevelopmental disorders. Methods: In the current investigation, we quantified expression levels of four...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819822/ https://www.ncbi.nlm.nih.gov/pubmed/31709263 http://dx.doi.org/10.3389/fmolb.2019.00113 |
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author | Hashemian, Fatemeh Ghafouri-Fard, Soudeh Arsang-Jang, Shahram Mirzajani, Sara Fallah, Hamid Mehvari Habibabadi, Jafar Sayad, Arezou Taheri, Mohammad |
author_facet | Hashemian, Fatemeh Ghafouri-Fard, Soudeh Arsang-Jang, Shahram Mirzajani, Sara Fallah, Hamid Mehvari Habibabadi, Jafar Sayad, Arezou Taheri, Mohammad |
author_sort | Hashemian, Fatemeh |
collection | PubMed |
description | Background: Long non-coding RNAs (lncRNAs) are a group of functional transcripts that are not translated to proteins. Recent investigations have underscored their role in the pathogenesis of neurodevelopmental disorders. Methods: In the current investigation, we quantified expression levels of four lncRNAs (HOXA-AS2, SPRY4-IT1, MEG3, and LINC-ROR) in peripheral blood of epileptic patients and normal controls. Results: Expression of HOXA-AS2 was significantly higher in patients compared with controls (Posterior beta = 1.982, P = 0.001). We detected interaction effects of gender on expression of HOXA-AS2 (P = 0.012). Further analyses showed over-expression of HOXA-AS2 in male patients compared with male controls (P = 0.003), in spite of similar levels of expression between female cases and female controls (P = 0.77). Expression of SPRY4-IT1 was higher in total patients compared with total controls (Posterior beta = 1.27, P = 0.02). Such difference was only observed between male patients and male controls when dividing study participants based on their gender (P = 0.012). There was no significant difference in expression of MEG3 and LINC-ROR between patients and controls. Conclusion: Expression levels of all lncRNAs were correlated with each other with r values ranging from 0.61 to 0.76 (P < 0.0001). However, expressions of none of lncRNAs were correlated with age of study participants. The current data implies a putative role for two lncRNAs in the pathogenesis of epilepsy and warrants future functional studies to verify the observed association. |
format | Online Article Text |
id | pubmed-6819822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68198222019-11-08 Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood Hashemian, Fatemeh Ghafouri-Fard, Soudeh Arsang-Jang, Shahram Mirzajani, Sara Fallah, Hamid Mehvari Habibabadi, Jafar Sayad, Arezou Taheri, Mohammad Front Mol Biosci Molecular Biosciences Background: Long non-coding RNAs (lncRNAs) are a group of functional transcripts that are not translated to proteins. Recent investigations have underscored their role in the pathogenesis of neurodevelopmental disorders. Methods: In the current investigation, we quantified expression levels of four lncRNAs (HOXA-AS2, SPRY4-IT1, MEG3, and LINC-ROR) in peripheral blood of epileptic patients and normal controls. Results: Expression of HOXA-AS2 was significantly higher in patients compared with controls (Posterior beta = 1.982, P = 0.001). We detected interaction effects of gender on expression of HOXA-AS2 (P = 0.012). Further analyses showed over-expression of HOXA-AS2 in male patients compared with male controls (P = 0.003), in spite of similar levels of expression between female cases and female controls (P = 0.77). Expression of SPRY4-IT1 was higher in total patients compared with total controls (Posterior beta = 1.27, P = 0.02). Such difference was only observed between male patients and male controls when dividing study participants based on their gender (P = 0.012). There was no significant difference in expression of MEG3 and LINC-ROR between patients and controls. Conclusion: Expression levels of all lncRNAs were correlated with each other with r values ranging from 0.61 to 0.76 (P < 0.0001). However, expressions of none of lncRNAs were correlated with age of study participants. The current data implies a putative role for two lncRNAs in the pathogenesis of epilepsy and warrants future functional studies to verify the observed association. Frontiers Media S.A. 2019-10-23 /pmc/articles/PMC6819822/ /pubmed/31709263 http://dx.doi.org/10.3389/fmolb.2019.00113 Text en Copyright © 2019 Hashemian, Ghafouri-Fard, Arsang-Jang, Mirzajani, Fallah, Mehvari Habibabadi, Sayad and Taheri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Hashemian, Fatemeh Ghafouri-Fard, Soudeh Arsang-Jang, Shahram Mirzajani, Sara Fallah, Hamid Mehvari Habibabadi, Jafar Sayad, Arezou Taheri, Mohammad Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title | Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title_full | Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title_fullStr | Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title_full_unstemmed | Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title_short | Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood |
title_sort | epilepsy is associated with dysregulation of long non-coding rnas in the peripheral blood |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819822/ https://www.ncbi.nlm.nih.gov/pubmed/31709263 http://dx.doi.org/10.3389/fmolb.2019.00113 |
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