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Changes in brain activity after weight loss

OBJECTIVES: The importance of the regulatory role of the brain in directing glucose homeostasis, energy homeostasis, eating behaviour, weight control and obesity is increasingly recognized. Brain activity in (sub)cortical neuronal networks involved in homeostatic control and hedonic responses is gen...

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Autores principales: van Opstal, A. M., Wijngaarden, M. A., van der Grond, J., Pijl, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819976/
https://www.ncbi.nlm.nih.gov/pubmed/31687170
http://dx.doi.org/10.1002/osp4.363
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author van Opstal, A. M.
Wijngaarden, M. A.
van der Grond, J.
Pijl, H.
author_facet van Opstal, A. M.
Wijngaarden, M. A.
van der Grond, J.
Pijl, H.
author_sort van Opstal, A. M.
collection PubMed
description OBJECTIVES: The importance of the regulatory role of the brain in directing glucose homeostasis, energy homeostasis, eating behaviour, weight control and obesity is increasingly recognized. Brain activity in (sub)cortical neuronal networks involved in homeostatic control and hedonic responses is generally increased in persons with obesity. Currently, it is not known if these functional changes can be affected by dieting. The aim of the current study was to investigate whether prolonged fasting and/or weight loss influences neuronal brain activity in obese persons. METHODS: Fourteen participants with obesity were included (two male participants and 12 female participants, body mass index 35.2 ± 1.2 kg m(−2)). Whole‐brain resting‐state functional magnetic resonance imaging was performed after an overnight fast, after a prolonged 48‐h fast and after an 8‐week weight loss intervention. RESULTS: An 8‐week weight loss intervention decreased BOLD signal in areas of the brain involved in salience, sensory motor and executive control. BOLD signal in these areas correlated with leptin levels and body mass index. CONCLUSIONS: Weight loss decreased activity in brain areas involved in feeding behaviour and reward processing. These results indicate that these obesity‐associated alterations in neuronal activity are related to excessive body weight and might change after weight loss.
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spelling pubmed-68199762019-11-04 Changes in brain activity after weight loss van Opstal, A. M. Wijngaarden, M. A. van der Grond, J. Pijl, H. Obes Sci Pract Original Articles OBJECTIVES: The importance of the regulatory role of the brain in directing glucose homeostasis, energy homeostasis, eating behaviour, weight control and obesity is increasingly recognized. Brain activity in (sub)cortical neuronal networks involved in homeostatic control and hedonic responses is generally increased in persons with obesity. Currently, it is not known if these functional changes can be affected by dieting. The aim of the current study was to investigate whether prolonged fasting and/or weight loss influences neuronal brain activity in obese persons. METHODS: Fourteen participants with obesity were included (two male participants and 12 female participants, body mass index 35.2 ± 1.2 kg m(−2)). Whole‐brain resting‐state functional magnetic resonance imaging was performed after an overnight fast, after a prolonged 48‐h fast and after an 8‐week weight loss intervention. RESULTS: An 8‐week weight loss intervention decreased BOLD signal in areas of the brain involved in salience, sensory motor and executive control. BOLD signal in these areas correlated with leptin levels and body mass index. CONCLUSIONS: Weight loss decreased activity in brain areas involved in feeding behaviour and reward processing. These results indicate that these obesity‐associated alterations in neuronal activity are related to excessive body weight and might change after weight loss. John Wiley and Sons Inc. 2019-08-24 /pmc/articles/PMC6819976/ /pubmed/31687170 http://dx.doi.org/10.1002/osp4.363 Text en © 2019 The Authors Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd Obesity Science & Practice This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
van Opstal, A. M.
Wijngaarden, M. A.
van der Grond, J.
Pijl, H.
Changes in brain activity after weight loss
title Changes in brain activity after weight loss
title_full Changes in brain activity after weight loss
title_fullStr Changes in brain activity after weight loss
title_full_unstemmed Changes in brain activity after weight loss
title_short Changes in brain activity after weight loss
title_sort changes in brain activity after weight loss
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819976/
https://www.ncbi.nlm.nih.gov/pubmed/31687170
http://dx.doi.org/10.1002/osp4.363
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