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Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies
Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newbor...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819984/ https://www.ncbi.nlm.nih.gov/pubmed/31687369 http://dx.doi.org/10.1183/23120541.00254-2018 |
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author | Bry, Charlotte Hubert, Dominique Reynaud-Gaubert, Martine Dromer, Claire Mal, Hervé Roux, Antoine Boussaud, Véronique Claustre, Johanna Le Pavec, Jérôme Murris-Espin, Muriel Danner-Boucher, Isabelle |
author_facet | Bry, Charlotte Hubert, Dominique Reynaud-Gaubert, Martine Dromer, Claire Mal, Hervé Roux, Antoine Boussaud, Véronique Claustre, Johanna Le Pavec, Jérôme Murris-Espin, Muriel Danner-Boucher, Isabelle |
author_sort | Bry, Charlotte |
collection | PubMed |
description | Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newborns were collected from nine transplantation centres. Mean age at time of pregnancy was 28 years. Cystic fibrosis affected 71% of patients. Mean±sd time between transplantation and pregnancy was 63±44 months. 26 births occurred (67%) with a mean term of 36 weeks of amenorrhoea and a mean birthweight of 2409 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in 1 s was 83.9% of predicted before pregnancy and 77.3% of predicted 1 year after the end of pregnancy (p=0.04). 10 patients developed chronic lung allograft dysfunction after delivery. Nine patients died at a mean±sd time after transplantation of 8.2±7 years and a mean±sd time after pregnancy of 4.6±6.5 years. These data show that pregnancy remains feasible in lung and heart–lung transplant recipients, with more frequent maternal and newborn complications than in the general population. Survival in this cohort appears to be similar to the global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial. |
format | Online Article Text |
id | pubmed-6819984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-68199842019-11-04 Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies Bry, Charlotte Hubert, Dominique Reynaud-Gaubert, Martine Dromer, Claire Mal, Hervé Roux, Antoine Boussaud, Véronique Claustre, Johanna Le Pavec, Jérôme Murris-Espin, Muriel Danner-Boucher, Isabelle ERJ Open Res Original Articles Pregnancy after lung and heart–lung transplantation remains rare. This French study deals with change in lung function after a pregnancy and the maternal and newborn outcomes. We retrospectively included 39 pregnancies in 35 women aged >20 years. Data on patients, course of pregnancies and newborns were collected from nine transplantation centres. Mean age at time of pregnancy was 28 years. Cystic fibrosis affected 71% of patients. Mean±sd time between transplantation and pregnancy was 63±44 months. 26 births occurred (67%) with a mean term of 36 weeks of amenorrhoea and a mean birthweight of 2409 g. Prematurity was observed in 11 cases (43%). Forced expiratory volume in 1 s was 83.9% of predicted before pregnancy and 77.3% of predicted 1 year after the end of pregnancy (p=0.04). 10 patients developed chronic lung allograft dysfunction after delivery. Nine patients died at a mean±sd time after transplantation of 8.2±7 years and a mean±sd time after pregnancy of 4.6±6.5 years. These data show that pregnancy remains feasible in lung and heart–lung transplant recipients, with more frequent maternal and newborn complications than in the general population. Survival in this cohort appears to be similar to the global survival observed in lung transplant recipients. Planned pregnancy and multidisciplinary follow-up are crucial. European Respiratory Society 2019-10-30 /pmc/articles/PMC6819984/ /pubmed/31687369 http://dx.doi.org/10.1183/23120541.00254-2018 Text en Copyright ©ERS 2019 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Original Articles Bry, Charlotte Hubert, Dominique Reynaud-Gaubert, Martine Dromer, Claire Mal, Hervé Roux, Antoine Boussaud, Véronique Claustre, Johanna Le Pavec, Jérôme Murris-Espin, Muriel Danner-Boucher, Isabelle Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title_full | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title_fullStr | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title_full_unstemmed | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title_short | Pregnancy after lung and heart–lung transplantation: a French multicentre retrospective study of 39 pregnancies |
title_sort | pregnancy after lung and heart–lung transplantation: a french multicentre retrospective study of 39 pregnancies |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819984/ https://www.ncbi.nlm.nih.gov/pubmed/31687369 http://dx.doi.org/10.1183/23120541.00254-2018 |
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