The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer

Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and radioresistance of cervical cancer. The componen...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Wang, Rensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Potential Biomarkers of Radiation Damage
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820189/
https://www.ncbi.nlm.nih.gov/pubmed/31695582
http://dx.doi.org/10.1177/1559325819885293
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author Liu, Chang
Wang, Rensheng
author_facet Liu, Chang
Wang, Rensheng
author_sort Liu, Chang
collection PubMed
description Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and radioresistance of cervical cancer. The components of Hedgehog signaling pathway could be biomarkers, related to progression and prognosis of cervical cancer. In addition, targeted therapy for Hedgehog signaling pathway is expected to become a new strategy for the treatment of radioresistant cervical cancer. This review summarizes the research status and progress of the relationship between radiation resistance and activation of Hedgehog signaling pathway in cervical cancer.
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spelling pubmed-68201892019-11-06 The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer Liu, Chang Wang, Rensheng Dose Response Potential Biomarkers of Radiation Damage Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and radioresistance of cervical cancer. The components of Hedgehog signaling pathway could be biomarkers, related to progression and prognosis of cervical cancer. In addition, targeted therapy for Hedgehog signaling pathway is expected to become a new strategy for the treatment of radioresistant cervical cancer. This review summarizes the research status and progress of the relationship between radiation resistance and activation of Hedgehog signaling pathway in cervical cancer. SAGE Publications 2019-10-28 /pmc/articles/PMC6820189/ /pubmed/31695582 http://dx.doi.org/10.1177/1559325819885293 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Potential Biomarkers of Radiation Damage
Liu, Chang
Wang, Rensheng
The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title_full The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title_fullStr The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title_full_unstemmed The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title_short The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
title_sort roles of hedgehog signaling pathway in radioresistance of cervical cancer
topic Potential Biomarkers of Radiation Damage
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820189/
https://www.ncbi.nlm.nih.gov/pubmed/31695582
http://dx.doi.org/10.1177/1559325819885293
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