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Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III

Group A rotavirus (RVA) genotype G12 has spread globally and has become one of the most prevalent genotypes of rotavirus in Africa. To understand the drivers for its genetic diversity and rapid spread we investigated the Bayesian phylogeography, viral evolution and population demography of Rotavirus...

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Autores principales: Motayo, Babatunde Olanrewaju, Oluwasemowo, Olukunle Oluwapamilerin, Olusola, Babatunde Adebiyi, Opayele, Adewale Victor, Faneye, Adedayo Omotayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820252/
https://www.ncbi.nlm.nih.gov/pubmed/31687512
http://dx.doi.org/10.1016/j.heliyon.2019.e02680
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author Motayo, Babatunde Olanrewaju
Oluwasemowo, Olukunle Oluwapamilerin
Olusola, Babatunde Adebiyi
Opayele, Adewale Victor
Faneye, Adedayo Omotayo
author_facet Motayo, Babatunde Olanrewaju
Oluwasemowo, Olukunle Oluwapamilerin
Olusola, Babatunde Adebiyi
Opayele, Adewale Victor
Faneye, Adedayo Omotayo
author_sort Motayo, Babatunde Olanrewaju
collection PubMed
description Group A rotavirus (RVA) genotype G12 has spread globally and has become one of the most prevalent genotypes of rotavirus in Africa. To understand the drivers for its genetic diversity and rapid spread we investigated the Bayesian phylogeography, viral evolution and population demography of Rotavirus G12 in Africa. We downloaded and aligned VP7 gene sequences of Rotavirus genotype G12, from thirteen African countries (n = 96). Phylogenetic analysis, Evolutionary analysis and Bayesian Phylogeography was carried out, using MEGA Vs 6, BEAST, and SPREAD3. Phylogenetic analysis revealed that all the African sequences fell into lineage III diversifying into two major clades. The evolutionary rate of the African rotavirus G12 sequences was 1.678×10(−3), (95% HPD, 1.201×10(−3) - 2.198×10(−3)) substitutions/site/year, with TMRC of 16.8 years. The Maximum clade credibility (MCC) tree clustered into three lineages (II, III, IV), African strains fell within lineage III, and diversified into three clusters. Phylogeography suggested that South Africa seemed to be the epicentre of dispersal of the genotype. The demographic history of the G12 viruses revealed a steady increase between the years1998–2007, followed by a sharp decrease in effective population size between the years 2008–2011. We have shown the potential for genetic diversification of Rotavirus genotype G12 in Africa. We recommend the adoption of Molecular surveillance across Africa to further control spread and diversification of Rotavirus.
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spelling pubmed-68202522019-11-04 Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III Motayo, Babatunde Olanrewaju Oluwasemowo, Olukunle Oluwapamilerin Olusola, Babatunde Adebiyi Opayele, Adewale Victor Faneye, Adedayo Omotayo Heliyon Article Group A rotavirus (RVA) genotype G12 has spread globally and has become one of the most prevalent genotypes of rotavirus in Africa. To understand the drivers for its genetic diversity and rapid spread we investigated the Bayesian phylogeography, viral evolution and population demography of Rotavirus G12 in Africa. We downloaded and aligned VP7 gene sequences of Rotavirus genotype G12, from thirteen African countries (n = 96). Phylogenetic analysis, Evolutionary analysis and Bayesian Phylogeography was carried out, using MEGA Vs 6, BEAST, and SPREAD3. Phylogenetic analysis revealed that all the African sequences fell into lineage III diversifying into two major clades. The evolutionary rate of the African rotavirus G12 sequences was 1.678×10(−3), (95% HPD, 1.201×10(−3) - 2.198×10(−3)) substitutions/site/year, with TMRC of 16.8 years. The Maximum clade credibility (MCC) tree clustered into three lineages (II, III, IV), African strains fell within lineage III, and diversified into three clusters. Phylogeography suggested that South Africa seemed to be the epicentre of dispersal of the genotype. The demographic history of the G12 viruses revealed a steady increase between the years1998–2007, followed by a sharp decrease in effective population size between the years 2008–2011. We have shown the potential for genetic diversification of Rotavirus genotype G12 in Africa. We recommend the adoption of Molecular surveillance across Africa to further control spread and diversification of Rotavirus. Elsevier 2019-10-21 /pmc/articles/PMC6820252/ /pubmed/31687512 http://dx.doi.org/10.1016/j.heliyon.2019.e02680 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Motayo, Babatunde Olanrewaju
Oluwasemowo, Olukunle Oluwapamilerin
Olusola, Babatunde Adebiyi
Opayele, Adewale Victor
Faneye, Adedayo Omotayo
Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title_full Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title_fullStr Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title_full_unstemmed Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title_short Phylogeography and evolutionary analysis of African Rotavirus a genotype G12 reveals district genetic diversification within lineage III
title_sort phylogeography and evolutionary analysis of african rotavirus a genotype g12 reveals district genetic diversification within lineage iii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820252/
https://www.ncbi.nlm.nih.gov/pubmed/31687512
http://dx.doi.org/10.1016/j.heliyon.2019.e02680
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