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Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and differen...

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Detalles Bibliográficos
Autores principales:	Li, Lili, Fan, Yichao, Huang, Xin, Luo, Jie, Zhong, Lan, Shu, Xing-sheng, Lu, Li, Xiang, Tingxiu, Chan, Anthony T.C., Yeo, Winnie, Chen, Ceshi, Chan, Wai Yee, Huganir, Richard L., Tao, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820368/ https://www.ncbi.nlm.nih.gov/pubmed/31654850 http://dx.doi.org/10.1016/j.isci.2019.10.007

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