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Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas
Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and differen...
Autores principales: | Li, Lili, Fan, Yichao, Huang, Xin, Luo, Jie, Zhong, Lan, Shu, Xing-sheng, Lu, Li, Xiang, Tingxiu, Chan, Anthony T.C., Yeo, Winnie, Chen, Ceshi, Chan, Wai Yee, Huganir, Richard L., Tao, Qian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820368/ https://www.ncbi.nlm.nih.gov/pubmed/31654850 http://dx.doi.org/10.1016/j.isci.2019.10.007 |
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