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Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report
Kimura's disease was first described by Kimura and Sceto in China in 1937. Kimura disease is a chronic inflammatory disorder of idiopathic etiology. The clinical presentation of Kimura's disease is painless solitary or multiple subcutaneous nodules, asymmetric, mostly in the head and neck...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820387/ https://www.ncbi.nlm.nih.gov/pubmed/31681687 http://dx.doi.org/10.4103/jfmpc.jfmpc_373_19 |
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author | Al Shammari, Faisal Nasiri, Abdulrahman Alkhathami, Mohammed Alawfi, Fahad Alfifi, Mohammed Al Otaibi, Eqab |
author_facet | Al Shammari, Faisal Nasiri, Abdulrahman Alkhathami, Mohammed Alawfi, Fahad Alfifi, Mohammed Al Otaibi, Eqab |
author_sort | Al Shammari, Faisal |
collection | PubMed |
description | Kimura's disease was first described by Kimura and Sceto in China in 1937. Kimura disease is a chronic inflammatory disorder of idiopathic etiology. The clinical presentation of Kimura's disease is painless solitary or multiple subcutaneous nodules, asymmetric, mostly in the head and neck region with often association with lymphadenopathy. Typically, the nodules are found on preauricular, submandibular, and popliteal regions as well as oral cavity, larynx, and parotid glands. In the present report, we describe a case of a 27-year-old male presented to our hospital with history of right neck and lip swelling for 10 days. In the history, the patient mentioned that he had bloody diarrhea four to six times day and he lost 10 kg in 1 month. The specimen was sent for histopathological examination which showed the lymph node architecture is preserved with significant increase number of eosinophils which is consistent with Kimura's disease. There is no agreement on the management aspects in Kimura's disease so far. The primary treatment for Kimura's disease includes surgical resection. Additional medical therapy including regional or systemic steroid therapy, cytotoxic therapy, and radiation has also been utilized. Considered as an inflammatory process, the disease has an excellent prognosis, although it may recur locally and wax and wane over time. |
format | Online Article Text |
id | pubmed-6820387 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-68203872019-11-01 Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report Al Shammari, Faisal Nasiri, Abdulrahman Alkhathami, Mohammed Alawfi, Fahad Alfifi, Mohammed Al Otaibi, Eqab J Family Med Prim Care Case Report Kimura's disease was first described by Kimura and Sceto in China in 1937. Kimura disease is a chronic inflammatory disorder of idiopathic etiology. The clinical presentation of Kimura's disease is painless solitary or multiple subcutaneous nodules, asymmetric, mostly in the head and neck region with often association with lymphadenopathy. Typically, the nodules are found on preauricular, submandibular, and popliteal regions as well as oral cavity, larynx, and parotid glands. In the present report, we describe a case of a 27-year-old male presented to our hospital with history of right neck and lip swelling for 10 days. In the history, the patient mentioned that he had bloody diarrhea four to six times day and he lost 10 kg in 1 month. The specimen was sent for histopathological examination which showed the lymph node architecture is preserved with significant increase number of eosinophils which is consistent with Kimura's disease. There is no agreement on the management aspects in Kimura's disease so far. The primary treatment for Kimura's disease includes surgical resection. Additional medical therapy including regional or systemic steroid therapy, cytotoxic therapy, and radiation has also been utilized. Considered as an inflammatory process, the disease has an excellent prognosis, although it may recur locally and wax and wane over time. Wolters Kluwer - Medknow 2019-09-30 /pmc/articles/PMC6820387/ /pubmed/31681687 http://dx.doi.org/10.4103/jfmpc.jfmpc_373_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Al Shammari, Faisal Nasiri, Abdulrahman Alkhathami, Mohammed Alawfi, Fahad Alfifi, Mohammed Al Otaibi, Eqab Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title | Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title_full | Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title_fullStr | Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title_full_unstemmed | Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title_short | Mepolizumab as an effective treatment for Kimura's disease associated with ulcerative colitis: A case report |
title_sort | mepolizumab as an effective treatment for kimura's disease associated with ulcerative colitis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820387/ https://www.ncbi.nlm.nih.gov/pubmed/31681687 http://dx.doi.org/10.4103/jfmpc.jfmpc_373_19 |
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