Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia

A 54-year-old male patient with acute lymphoblastic leukemia was referred to the Department of Oral Medicine. He had a primary refractory disease and was treated according to HOVON71 and HAM protocol. Sixteen days after the start of the HAM protocol the patient developed palatal dark red/brownish le...

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Autores principales: Vučićević Boras, Vanja, Jurlina, Martin, Brailo, Vlaho, Đurić Vuković, Katarina, Rončević, Pavle, Bašić Kinda, Sandra, Vidović Juras, Danica, Gabrić, Dragana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: University of Zagreb School of Dental Medicine, and Croatian Dental Society - Croatian Medical Association 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820447/
https://www.ncbi.nlm.nih.gov/pubmed/31749459
http://dx.doi.org/10.15644/asc53/3/9
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author Vučićević Boras, Vanja
Jurlina, Martin
Brailo, Vlaho
Đurić Vuković, Katarina
Rončević, Pavle
Bašić Kinda, Sandra
Vidović Juras, Danica
Gabrić, Dragana
author_facet Vučićević Boras, Vanja
Jurlina, Martin
Brailo, Vlaho
Đurić Vuković, Katarina
Rončević, Pavle
Bašić Kinda, Sandra
Vidović Juras, Danica
Gabrić, Dragana
author_sort Vučićević Boras, Vanja
collection PubMed
description A 54-year-old male patient with acute lymphoblastic leukemia was referred to the Department of Oral Medicine. He had a primary refractory disease and was treated according to HOVON71 and HAM protocol. Sixteen days after the start of the HAM protocol the patient developed palatal dark red/brownish lesion and maxillary vestibular exophytic lesion. Biopsy specimens from oral lesions were taken and microbiologic evaluation confirmed the presence of Aspergillus fumigatus and Rhizopus genus. The treatment of the patient consisted of the inferior maxillectomy and intravenous posaconazole and amphotericine B for the following 28 days. Since the coinfection with Aspergillus and Rhizopus is extremely rarely seen in the oral cavity, a diagnostic and therapeutic dilemma easily presents itself.
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spelling pubmed-68204472019-11-20 Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia Vučićević Boras, Vanja Jurlina, Martin Brailo, Vlaho Đurić Vuković, Katarina Rončević, Pavle Bašić Kinda, Sandra Vidović Juras, Danica Gabrić, Dragana Acta Stomatol Croat Case Report A 54-year-old male patient with acute lymphoblastic leukemia was referred to the Department of Oral Medicine. He had a primary refractory disease and was treated according to HOVON71 and HAM protocol. Sixteen days after the start of the HAM protocol the patient developed palatal dark red/brownish lesion and maxillary vestibular exophytic lesion. Biopsy specimens from oral lesions were taken and microbiologic evaluation confirmed the presence of Aspergillus fumigatus and Rhizopus genus. The treatment of the patient consisted of the inferior maxillectomy and intravenous posaconazole and amphotericine B for the following 28 days. Since the coinfection with Aspergillus and Rhizopus is extremely rarely seen in the oral cavity, a diagnostic and therapeutic dilemma easily presents itself. University of Zagreb School of Dental Medicine, and Croatian Dental Society - Croatian Medical Association 2019-09 /pmc/articles/PMC6820447/ /pubmed/31749459 http://dx.doi.org/10.15644/asc53/3/9 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Case Report
Vučićević Boras, Vanja
Jurlina, Martin
Brailo, Vlaho
Đurić Vuković, Katarina
Rončević, Pavle
Bašić Kinda, Sandra
Vidović Juras, Danica
Gabrić, Dragana
Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title_full Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title_fullStr Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title_full_unstemmed Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title_short Oral Mucormycosis and Aspergillosis in the Patient with Acute Leukemia
title_sort oral mucormycosis and aspergillosis in the patient with acute leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820447/
https://www.ncbi.nlm.nih.gov/pubmed/31749459
http://dx.doi.org/10.15644/asc53/3/9
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