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Increased yields and biological potency of knob-into-hole-based soluble MHC class II molecules

Assembly of soluble peptide-major histocompatibility complex class II (pMHCII) monomers into multimeric structures enables the detection of antigen-specific CD4(+) T cells in biological samples and, in some configurations, their reprogramming in vivo. Unfortunately, current MHCII-αβ chain heterodime...

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Detalles Bibliográficos
Autores principales:	Serra, Pau, Garabatos, Nahir, Singha, Santiswarup, Fandos, César, Garnica, Josep, Solé, Patricia, Parras, Daniel, Yamanouchi, Jun, Blanco, Jesús, Tort, Meritxell, Ortega, Mireia, Yang, Yang, Ellestad, Kristofor K., Santamaria, Pere
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820532/ https://www.ncbi.nlm.nih.gov/pubmed/31664029 http://dx.doi.org/10.1038/s41467-019-12902-2

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