Focal segmental glomerulosclerosis ACTN4 mutants binding to actin: regulation by phosphomimetic mutations

Natural mutations such as lysine 255 to glutamic acid (K to E), threonine 259 to isoleucine (T to I) and serine 262 to proline (S to P) that occur within the actin binding domain of alpha-actinin-4 (ACTN4) cause an autosomal dominant form of focal segmental glomerulosclerosis (FSGS) in affected huma...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Hanshuang, Wingert, Bentley, Weins, Astrid, Pollak, Martin R., Camacho, Carlos, Wells, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820738/
https://www.ncbi.nlm.nih.gov/pubmed/31664084
http://dx.doi.org/10.1038/s41598-019-51825-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820738/
https://www.ncbi.nlm.nih.gov/pubmed/31664084
http://dx.doi.org/10.1038/s41598-019-51825-2

Ejemplares similares