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Altered temporal sensitivity in obesity is linked to pro-inflammatory state

Temporal sensitivity to multisensory stimuli has been shown to be reduced in obesity. We sought to investigate the possible role of the pro-inflammatory state on such alteration, considering the effect of the expression of markers, such as leptin and IL6, which are notably high in obesity. The perfo...

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Autores principales: Scarpina, Federica, Marzullo, Paolo, Mai, Stefania, Mauro, Alessandro, Scacchi, Massimo, Costantini, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820747/
https://www.ncbi.nlm.nih.gov/pubmed/31664059
http://dx.doi.org/10.1038/s41598-019-51660-5
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author Scarpina, Federica
Marzullo, Paolo
Mai, Stefania
Mauro, Alessandro
Scacchi, Massimo
Costantini, Marcello
author_facet Scarpina, Federica
Marzullo, Paolo
Mai, Stefania
Mauro, Alessandro
Scacchi, Massimo
Costantini, Marcello
author_sort Scarpina, Federica
collection PubMed
description Temporal sensitivity to multisensory stimuli has been shown to be reduced in obesity. We sought to investigate the possible role of the pro-inflammatory state on such alteration, considering the effect of the expression of markers, such as leptin and IL6, which are notably high in obesity. The performance of 15 male individuals affected by obesity and 15 normal-weight males was compared using two audiovisual temporal tasks, namely simultaneity judgment and temporal order judgment. Analyses of serum levels of inflammatory markers of leptin and IL6, and of neurotrophic factors of BDNF and S100SB were quantified. At the behavioral level we confirmed previous evidence showing poorer temporal sensitivity in obesity compared to normal-weight participants. Furthermore, leptin, that is a cytokine overexpressed in obesity, represented the best predictor of behavioral differences between groups in both tasks. The hypothesis we put forward is that the immune system, rather than overall cerebral dysfunction, might contribute to explain the altered temporal sensitivity in obesity. The present finding is discussed within the context of the role of cytokines on the brain mechanisms supporting temporal sensitivity.
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spelling pubmed-68207472019-11-04 Altered temporal sensitivity in obesity is linked to pro-inflammatory state Scarpina, Federica Marzullo, Paolo Mai, Stefania Mauro, Alessandro Scacchi, Massimo Costantini, Marcello Sci Rep Article Temporal sensitivity to multisensory stimuli has been shown to be reduced in obesity. We sought to investigate the possible role of the pro-inflammatory state on such alteration, considering the effect of the expression of markers, such as leptin and IL6, which are notably high in obesity. The performance of 15 male individuals affected by obesity and 15 normal-weight males was compared using two audiovisual temporal tasks, namely simultaneity judgment and temporal order judgment. Analyses of serum levels of inflammatory markers of leptin and IL6, and of neurotrophic factors of BDNF and S100SB were quantified. At the behavioral level we confirmed previous evidence showing poorer temporal sensitivity in obesity compared to normal-weight participants. Furthermore, leptin, that is a cytokine overexpressed in obesity, represented the best predictor of behavioral differences between groups in both tasks. The hypothesis we put forward is that the immune system, rather than overall cerebral dysfunction, might contribute to explain the altered temporal sensitivity in obesity. The present finding is discussed within the context of the role of cytokines on the brain mechanisms supporting temporal sensitivity. Nature Publishing Group UK 2019-10-29 /pmc/articles/PMC6820747/ /pubmed/31664059 http://dx.doi.org/10.1038/s41598-019-51660-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Scarpina, Federica
Marzullo, Paolo
Mai, Stefania
Mauro, Alessandro
Scacchi, Massimo
Costantini, Marcello
Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title_full Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title_fullStr Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title_full_unstemmed Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title_short Altered temporal sensitivity in obesity is linked to pro-inflammatory state
title_sort altered temporal sensitivity in obesity is linked to pro-inflammatory state
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820747/
https://www.ncbi.nlm.nih.gov/pubmed/31664059
http://dx.doi.org/10.1038/s41598-019-51660-5
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