Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid fibrils from meningeal Alzheimer’s brain tiss...

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Detalles Bibliográficos
Autores principales: Kollmer, Marius, Close, William, Funk, Leonie, Rasmussen, Jay, Bsoul, Aref, Schierhorn, Angelika, Schmidt, Matthias, Sigurdson, Christina J., Jucker, Mathias, Fändrich, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820800/
https://www.ncbi.nlm.nih.gov/pubmed/31664019
http://dx.doi.org/10.1038/s41467-019-12683-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820800/
https://www.ncbi.nlm.nih.gov/pubmed/31664019
http://dx.doi.org/10.1038/s41467-019-12683-8

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