TGF-β1-induced HSP47 regulates extracellular matrix accumulation via Smad2/3 signaling pathways in nasal fibroblasts

HSP47 is required for the production of collagen and serves an important role in tissue remodeling, a pathophysiologic mechanism of chronic rhinosinusitis (CRS). We investigated the relationship between HSP47 expression and tissue remodeling in CRS. We also determined the underlying molecular mechan...

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Detalles Bibliográficos
Autores principales: Kim, Hae-Ji, Park, Joo-Hoo, Shin, Jae-Min, Yang, Hyun-Woo, Lee, Heung-Man, Park, Il-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820875/
https://www.ncbi.nlm.nih.gov/pubmed/31664133
http://dx.doi.org/10.1038/s41598-019-52064-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820875/
https://www.ncbi.nlm.nih.gov/pubmed/31664133
http://dx.doi.org/10.1038/s41598-019-52064-1

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