Cargando…

Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer

BACKGROUND: The treatment of endometrial cancer (EC), the most common gynecological cancer, is currently hampered by the toxicity of current cytotoxic agents, meaning novel therapeutic approaches are urgently required. METHODS: A cohort of 161 patients was evaluated for the expression of the recepto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Healey, Gareth D., Pan-Castillo, Belen, Garcia-Parra, Jezabel, Davies, Julia, Roberts, Shaun, Jones, Eilir, Dhar, Kalyan, Nandanan, Sarika, Tofazzal, Nasima, Piggott, Luke, Clarkson, Richard, Seaton, Gillian, Frostell, Asa, Fagge, Tim, McKee, Colin, Margarit, Lavinia, Conlan, R. Steven, Gonzalez, Deyarina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820928/ https://www.ncbi.nlm.nih.gov/pubmed/31665084 http://dx.doi.org/10.1186/s40425-019-0765-z

Ejemplares similares

A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development
por: Healey, Gareth D., et al.
Publicado: (2019)

Dinaciclib, a Bimodal Agent Effective against Endometrial Cancer
por: Howard, David, et al.
Publicado: (2021)

Mechanomimetic 3D Scaffolds as a Humanized In Vitro Model for Ovarian Cancer
por: Paradiso, Francesca, et al.
Publicado: (2022)

Chronic Urinary Infection in Overactive Bladder Syndrome: A Prospective, Blinded Case Control Study
por: Khan, Zainab, et al.
Publicado: (2021)

Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract
por: Pisano, Simone, et al.
Publicado: (2019)

Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer
por: Howard, David, et al.
Publicado: (2022)

Therapeutic Potential of Microalgae-Derived Bioactive Metabolites Is Influenced by Different Large-Scale Culture Strategies
por: Garcia-Parra, Jezabel, et al.
Publicado: (2022)

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation
por: Sparvero, Louis J, et al.
Publicado: (2009)

Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11
por: Younas, Kinza, et al.
Publicado: (2019)

The Receptor for Advanced Glycation End Products (RAGE) and the Lung
por: Buckley, Stephen T., et al.
Publicado: (2010)

The role of receptor for advanced glycation endproducts (RAGE) in infection
por: van Zoelen , Marieke AD, et al.
Publicado: (2011)

The Role of Receptor for Advanced Glycation Endproducts (RAGE) in Infection
por: van Zoelen, M. A. D., et al.
Publicado: (2011)

Soluble Forms of the Receptor for Advanced Glycation Endproducts (RAGE) in Periodontitis
por: Detzen, Laurent, et al.
Publicado: (2019)

The receptor for advanced glycation endproducts (RAGE) modulates T cell signaling
por: Reed, James C., et al.
Publicado: (2020)

Strategies for PET imaging of the receptor for advanced glycation endproducts (RAGE)
por: Drake, Lindsey R., et al.
Publicado: (2020)

Elucidating Novel Targets for Ovarian Cancer Antibody–Drug Conjugate Development: Integrating In Silico Prediction and Surface Plasmon Resonance to Identify Targets with Enhanced Antibody Internalization Capacity
por: Onyido, Emenike Kenechi, et al.
Publicado: (2023)

Polymorphisms −374 T/A and −429 T/C of the Receptor for Advanced Glycation End-Products (RAGE) and Serum Levels of RAGE (sRAGE) Are Not Associated with Metabolic Syndrome
por: González-Guerrero, Diana Elizabeth, et al.
Publicado: (2023)

RAGE, Receptor of Advanced Glycation Endoproducts, Negatively Regulates Chondrocytes Differentiation
por: Kosaka, Tatsuya, et al.
Publicado: (2014)

Role of receptor for advanced glycation end products (RAGE) in liver disease
por: Yamagishi, Sho-ichi, et al.
Publicado: (2015)

Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer
por: Taneja, Sakshi, et al.
Publicado: (2021)

Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients
por: Lazzari, Tássia Kirchmann, et al.
Publicado: (2021)

The Potential Influence of Advanced Glycation End Products and (s)RAGE in Rheumatic Diseases
por: Delrue, Charlotte, et al.
Publicado: (2023)

RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions
por: Gelain, Daniel Pens, et al.
Publicado: (2023)

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands
por: Yao, Dachun, et al.
Publicado: (2010)

In Patients with Chronic Kidney Disease Advanced Glycation End-Products Receptors Isoforms (sRAGE and esRAGE) Are Associated with Malnutrition
por: Caldiroli, Lara, et al.
Publicado: (2022)

The Role of Receptor for Advanced Glycation End Products (RAGE) in the Proliferation of Hepatocellular Carcinoma
por: Yaser, Al-Madhagi, et al.
Publicado: (2012)

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity
por: Teismann, Peter, et al.
Publicado: (2012)

The Receptor for Advanced Glycation End Products (RAGE) Contributes to the Progression of Emphysema in Mice
por: Sambamurthy, Nisha, et al.
Publicado: (2015)

The Receptor for Advanced Glycation End Products (RAGE) Is Associated with Persistent Atrial Fibrillation
por: Lancefield, Terase F., et al.
Publicado: (2016)

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective
por: Bongarzone, Salvatore, et al.
Publicado: (2017)

Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes
por: Yang, Yan, et al.
Publicado: (2022)

Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
por: Gutowska, Klaudia, et al.
Publicado: (2023)

Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases
por: Lee, Eun Ji, et al.
Publicado: (2013)

SUN-LB131 Association of Receptor for Advanced Glycation End Product (RAGE) Gene Polymorphisms & Serum Levels of Soluble RAGE (sRAGE) With Metabolic Syndrome (MS) in Mexican Population
por: Gonzalez-Guerrero, Diana Elizabeth, et al.
Publicado: (2020)

Polymorphisms in the receptor for advanced glycation end-products (RAGE) gene and circulating RAGE levels as a susceptibility factor for non-alcoholic steatohepatitis (NASH)
por: Mehta, Rohini, et al.
Publicado: (2018)

The Remarkable Roles of the Receptor for Advanced Glycation End Products (RAGE) and Its Soluble Isoforms in COVID-19: The Importance of RAGE Pathway in the Lung Injuries
por: Salehi, Mitra, et al.
Publicado: (2022)

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes
por: Soro-Paavonen, Aino, et al.
Publicado: (2008)

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs
por: Xue, Jing, et al.
Publicado: (2014)

Overexpression of the Receptor for Advanced Glycation Endproducts (RAGE) Is Associated with Poor Prognosis in Gastric Cancer
por: Wang, Da, et al.
Publicado: (2015)

Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction
por: Fracasso, Bianca de Moraes, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ohdke45b2fvnm748inrkhg5j61