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Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study

BACKGROUND: Frailty status is recognized as an important parameter in critically ill elderly patients, but nothing is known about outcomes in non-frail patients regarding the development of frailty or frailty and death after intensive care. The aim of this study was to determine risk factors for fra...

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Autores principales: Launey, Yoann, Jacquet, Hervé, Arnouat, Matthieu, Rousseau, Chloe, Nesseler, Nicolas, Seguin, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820956/
https://www.ncbi.nlm.nih.gov/pubmed/31687161
http://dx.doi.org/10.1186/s40560-019-0403-3
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author Launey, Yoann
Jacquet, Hervé
Arnouat, Matthieu
Rousseau, Chloe
Nesseler, Nicolas
Seguin, Philippe
author_facet Launey, Yoann
Jacquet, Hervé
Arnouat, Matthieu
Rousseau, Chloe
Nesseler, Nicolas
Seguin, Philippe
author_sort Launey, Yoann
collection PubMed
description BACKGROUND: Frailty status is recognized as an important parameter in critically ill elderly patients, but nothing is known about outcomes in non-frail patients regarding the development of frailty or frailty and death after intensive care. The aim of this study was to determine risk factors for frailty and death or only frailty 6 months after intensive care unit (ICU) admission in non-frail patients ≥ 65 years. METHODS: A prospective non-interventional study performed in an academic ICU from February 2015 to February 2016 included non-frail ≥ 65-year-old patients hospitalized for > 24 h in the ICU. Frailty was assessed by calculating the frailty index (FI) at admission and 6 months later. Patients who remained non-frail (FI < 0.2) were compared to patients who presented frailty (FI ≥ 0.2) and those who presented frailty and death at 6 months. RESULTS: Among 974 admissions, 136 patients were eligible for the study and 88 patients were analysed at 6 months (non-frail n = 34, frail n = 29, death n = 25). Multivariable analysis showed that mechanical ventilation duration was an independent risk factor for frailty/death at 6 months (per day of mechanical ventilation, odds ratio [OR] = 1.11; 95% confidence interval [CI] 1.04–1.19, p = 0.002). When excluding patients who died, mechanical ventilation duration remained the sole risk factor for frailty at 6 months (OR = 1.19; 95% CI 1.07–1.33, p = 0.001). CONCLUSION: Mechanical ventilation duration was the sole predictive factor of frailty and death or only frailty 6 months after ICU hospitalization in initially non-frail patients.
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spelling pubmed-68209562019-11-04 Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study Launey, Yoann Jacquet, Hervé Arnouat, Matthieu Rousseau, Chloe Nesseler, Nicolas Seguin, Philippe J Intensive Care Research BACKGROUND: Frailty status is recognized as an important parameter in critically ill elderly patients, but nothing is known about outcomes in non-frail patients regarding the development of frailty or frailty and death after intensive care. The aim of this study was to determine risk factors for frailty and death or only frailty 6 months after intensive care unit (ICU) admission in non-frail patients ≥ 65 years. METHODS: A prospective non-interventional study performed in an academic ICU from February 2015 to February 2016 included non-frail ≥ 65-year-old patients hospitalized for > 24 h in the ICU. Frailty was assessed by calculating the frailty index (FI) at admission and 6 months later. Patients who remained non-frail (FI < 0.2) were compared to patients who presented frailty (FI ≥ 0.2) and those who presented frailty and death at 6 months. RESULTS: Among 974 admissions, 136 patients were eligible for the study and 88 patients were analysed at 6 months (non-frail n = 34, frail n = 29, death n = 25). Multivariable analysis showed that mechanical ventilation duration was an independent risk factor for frailty/death at 6 months (per day of mechanical ventilation, odds ratio [OR] = 1.11; 95% confidence interval [CI] 1.04–1.19, p = 0.002). When excluding patients who died, mechanical ventilation duration remained the sole risk factor for frailty at 6 months (OR = 1.19; 95% CI 1.07–1.33, p = 0.001). CONCLUSION: Mechanical ventilation duration was the sole predictive factor of frailty and death or only frailty 6 months after ICU hospitalization in initially non-frail patients. BioMed Central 2019-10-30 /pmc/articles/PMC6820956/ /pubmed/31687161 http://dx.doi.org/10.1186/s40560-019-0403-3 Text en © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Launey, Yoann
Jacquet, Hervé
Arnouat, Matthieu
Rousseau, Chloe
Nesseler, Nicolas
Seguin, Philippe
Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title_full Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title_fullStr Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title_full_unstemmed Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title_short Risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
title_sort risk factors of frailty and death or only frailty after intensive care in non-frail elderly patients: a prospective non-interventional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820956/
https://www.ncbi.nlm.nih.gov/pubmed/31687161
http://dx.doi.org/10.1186/s40560-019-0403-3
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