Arabidopsis thaliana alternative dehydrogenases: a potential therapy for mitochondrial complex I deficiency? Perspectives and pitfalls

BACKGROUND: Complex I (CI or NADH:ubiquinone oxidoreductase) deficiency is the most frequent cause of mitochondrial respiratory chain defect. Successful attempts to rescue CI function by introducing an exogenous NADH dehydrogenase, such as the NDI1 from Saccharomyces cerevisiae (ScNDI1), have been r...

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Detalles Bibliográficos
Autores principales: Catania, Alessia, Iuso, Arcangela, Bouchereau, Juliette, Kremer, Laura S., Paviolo, Marina, Terrile, Caterina, Bénit, Paule, Rasmusson, Allan G., Schwarzmayr, Thomas, Tiranti, Valeria, Rustin, Pierre, Rak, Malgorzata, Prokisch, Holger, Schiff, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821020/
https://www.ncbi.nlm.nih.gov/pubmed/31665043
http://dx.doi.org/10.1186/s13023-019-1185-3

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