Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

BACKGROUND: IL-10 knockout (KO) mice are protected from experimental autoimmune encephalomyelitis (EAE) with low-dose estrogen (E2) treatment similar to wild-type (WT) mice. Previous studies have demonstrated a decrease in tumor necrosis factor in all E2-treated groups, which led to the protection o...

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Detalles Bibliográficos
Autores principales: Seifert, Hilary A., Gerstner, Grant, Kent, Gail, Vandenbark, Arthur A., Offner, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821034/
https://www.ncbi.nlm.nih.gov/pubmed/31665042
http://dx.doi.org/10.1186/s12974-019-1588-z

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