LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Activation of ribosomal RNA (rRNA) synthesis is pivotal during cell growth and proliferation, but its aberrant upregulation may promote tumorigenesis. Here, we demonstrate that the candidate oncoprotein, LYAR, enhances ribosomal DNA (rDNA) transcription. Our data reveal that LYAR binds the histone-a...

Descripción completa

Detalles Bibliográficos
Autores principales: Izumikawa, Keiichi, Ishikawa, Hideaki, Yoshikawa, Harunori, Fujiyama, Sally, Watanabe, Akira, Aburatani, Hiroyuki, Tachikawa, Hiroyuki, Hayano, Toshiya, Miura, Yutaka, Isobe, Toshiaki, Simpson, Richard J, Li, Li, Min, Jinrong, Takahashi, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821171/
https://www.ncbi.nlm.nih.gov/pubmed/31504794
http://dx.doi.org/10.1093/nar/gkz747

Ejemplares similares

Ejemplares similares