Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNA(Met), all 8 tRNAs and ND6 mRNA in the light-strand transcript

Mitochondrial tRNA processing defects were associated with human diseases but their pathophysiology remains elusively. The hypertension-associated m.4401A>G mutation resided at a spacer between mitochondrial tRNA(Met) and tRNA(Gln) genes. An in vitro processing experiment revealed that the m.4401...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaoxu, Cui, Limei, Xiao, Yun, Mao, Qin, Aishanjiang, Maerhaba, Kong, Wanzhong, Liu, Yuqi, Chen, Hong, Hong, Fang, Jia, Zidong, Wang, Meng, Jiang, Pingping, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821173/
https://www.ncbi.nlm.nih.gov/pubmed/31504769
http://dx.doi.org/10.1093/nar/gkz742

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