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Post-transcriptional negative feedback regulation of proteostasis through the Dis3 ribonuclease and its disruption by polyQ-expanded Huntingtin

When proteostasis is disrupted by stresses such as heat shock, the heat stress response will be stimulated, leading to up-regulation of molecular chaperones by transcriptional activation and mRNA stabilization for restoring proteostasis. Although the mechanisms for their transcriptional activation h...

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Detalles Bibliográficos
Autores principales:	Kong, Ka-Yiu Edwin, Hung, Ting-Ngai Felix, Man, Pui-Hei Marcus, Wong, Tin-Ning, Cheng, Tao, Jin, Dong-Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821268/ https://www.ncbi.nlm.nih.gov/pubmed/31428776 http://dx.doi.org/10.1093/nar/gkz722

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