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Dynamical ensemble of the active state and transition state mimic for the RNA-cleaving 8–17 DNAzyme in solution
We perform molecular dynamics simulations, based on recent crystallographic data, on the 8–17 DNAzyme at four states along the reaction pathway to determine the dynamical ensemble for the active state and transition state mimic in solution. A striking finding is the diverse roles played by Na(+) and...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821293/ https://www.ncbi.nlm.nih.gov/pubmed/31511899 http://dx.doi.org/10.1093/nar/gkz773 |