Cargando…

How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?

BACKGROUND: The World Health Organization now recommends the use of typhoid conjugate vaccines (TCVs) in typhoid-endemic countries, and Gavi, the Vaccine Alliance, added TCVs into the portfolio of subsidized vaccines. Data from the Severe Typhoid Fever in Africa (SETA) program were used to contribut...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeon, Hyon Jin, Im, Justin, Haselbeck, Andrea, Holm, Marianne, Rakotozandrindrainy, Raphaël, Bassiahi, Abdramane Soura, Panzner, Ursula, Mogeni, Ondari D, Seo, Hye Jin, Lunguya, Octavie, Jacobs, Jan, Okeke, Iruka N, Terferi, Mekonnen, Owusu-Dabo, Ellis, Dougan, Gordon, Carey, Megan, Steele, A Duncan, Kim, Jerome H, Clemens, John D, Andrews, Jason R, Park, Se Eun, Baker, Stephen, Marks, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821306/
https://www.ncbi.nlm.nih.gov/pubmed/31665772
http://dx.doi.org/10.1093/cid/ciz629
_version_ 1783464120111071232
author Jeon, Hyon Jin
Im, Justin
Haselbeck, Andrea
Holm, Marianne
Rakotozandrindrainy, Raphaël
Bassiahi, Abdramane Soura
Panzner, Ursula
Mogeni, Ondari D
Seo, Hye Jin
Lunguya, Octavie
Jacobs, Jan
Okeke, Iruka N
Terferi, Mekonnen
Owusu-Dabo, Ellis
Dougan, Gordon
Carey, Megan
Steele, A Duncan
Kim, Jerome H
Clemens, John D
Andrews, Jason R
Park, Se Eun
Baker, Stephen
Marks, Florian
author_facet Jeon, Hyon Jin
Im, Justin
Haselbeck, Andrea
Holm, Marianne
Rakotozandrindrainy, Raphaël
Bassiahi, Abdramane Soura
Panzner, Ursula
Mogeni, Ondari D
Seo, Hye Jin
Lunguya, Octavie
Jacobs, Jan
Okeke, Iruka N
Terferi, Mekonnen
Owusu-Dabo, Ellis
Dougan, Gordon
Carey, Megan
Steele, A Duncan
Kim, Jerome H
Clemens, John D
Andrews, Jason R
Park, Se Eun
Baker, Stephen
Marks, Florian
author_sort Jeon, Hyon Jin
collection PubMed
description BACKGROUND: The World Health Organization now recommends the use of typhoid conjugate vaccines (TCVs) in typhoid-endemic countries, and Gavi, the Vaccine Alliance, added TCVs into the portfolio of subsidized vaccines. Data from the Severe Typhoid Fever in Africa (SETA) program were used to contribute to TCV introduction decision-making processes, exemplified for Ghana and Madagascar. METHODS: Data collected from both countries were evaluated, and barriers to and benefits of introduction scenarios are discussed. No standardized methodological framework was applied. RESULTS: The Ghanaian healthcare system differs from its Malagasy counterpart: Ghana features a functioning insurance system, antimicrobials are available nationwide, and several sites in Ghana deploy blood culture–based typhoid diagnosis. A higher incidence of antimicrobial-resistant Salmonella Typhi is reported in Ghana, which has not been identified as an issue in Madagascar. The Malagasy people have a low expectation of provided healthcare and experience frequent unavailability of medicines, resulting in limited healthcare-seeking behavior and extended consequences of untreated disease. CONCLUSIONS: For Ghana, high typhoid fever incidence coupled with spatiotemporal heterogeneity was observed. A phased TCV introduction through an initial mass campaign in high-risk areas followed by inclusion into routine national immunizations prior to expansion to other areas of the country can be considered. For Madagascar, a national mass campaign followed by routine introduction would be the introduction scenario of choice as it would protect the population, reduce transmission, and prevent an often-deadly disease in a setting characterized by lack of access to healthcare infrastructure. New, easy-to-use diagnostic tools, potentially including environmental surveillance, should be explored and improved to facilitate identification of high-risk areas.
format Online
Article
Text
id pubmed-6821306
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-68213062019-11-04 How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines? Jeon, Hyon Jin Im, Justin Haselbeck, Andrea Holm, Marianne Rakotozandrindrainy, Raphaël Bassiahi, Abdramane Soura Panzner, Ursula Mogeni, Ondari D Seo, Hye Jin Lunguya, Octavie Jacobs, Jan Okeke, Iruka N Terferi, Mekonnen Owusu-Dabo, Ellis Dougan, Gordon Carey, Megan Steele, A Duncan Kim, Jerome H Clemens, John D Andrews, Jason R Park, Se Eun Baker, Stephen Marks, Florian Clin Infect Dis Supplement Articles BACKGROUND: The World Health Organization now recommends the use of typhoid conjugate vaccines (TCVs) in typhoid-endemic countries, and Gavi, the Vaccine Alliance, added TCVs into the portfolio of subsidized vaccines. Data from the Severe Typhoid Fever in Africa (SETA) program were used to contribute to TCV introduction decision-making processes, exemplified for Ghana and Madagascar. METHODS: Data collected from both countries were evaluated, and barriers to and benefits of introduction scenarios are discussed. No standardized methodological framework was applied. RESULTS: The Ghanaian healthcare system differs from its Malagasy counterpart: Ghana features a functioning insurance system, antimicrobials are available nationwide, and several sites in Ghana deploy blood culture–based typhoid diagnosis. A higher incidence of antimicrobial-resistant Salmonella Typhi is reported in Ghana, which has not been identified as an issue in Madagascar. The Malagasy people have a low expectation of provided healthcare and experience frequent unavailability of medicines, resulting in limited healthcare-seeking behavior and extended consequences of untreated disease. CONCLUSIONS: For Ghana, high typhoid fever incidence coupled with spatiotemporal heterogeneity was observed. A phased TCV introduction through an initial mass campaign in high-risk areas followed by inclusion into routine national immunizations prior to expansion to other areas of the country can be considered. For Madagascar, a national mass campaign followed by routine introduction would be the introduction scenario of choice as it would protect the population, reduce transmission, and prevent an often-deadly disease in a setting characterized by lack of access to healthcare infrastructure. New, easy-to-use diagnostic tools, potentially including environmental surveillance, should be explored and improved to facilitate identification of high-risk areas. Oxford University Press 2019-11-15 2019-10-30 /pmc/articles/PMC6821306/ /pubmed/31665772 http://dx.doi.org/10.1093/cid/ciz629 Text en © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Jeon, Hyon Jin
Im, Justin
Haselbeck, Andrea
Holm, Marianne
Rakotozandrindrainy, Raphaël
Bassiahi, Abdramane Soura
Panzner, Ursula
Mogeni, Ondari D
Seo, Hye Jin
Lunguya, Octavie
Jacobs, Jan
Okeke, Iruka N
Terferi, Mekonnen
Owusu-Dabo, Ellis
Dougan, Gordon
Carey, Megan
Steele, A Duncan
Kim, Jerome H
Clemens, John D
Andrews, Jason R
Park, Se Eun
Baker, Stephen
Marks, Florian
How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title_full How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title_fullStr How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title_full_unstemmed How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title_short How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?
title_sort how can the typhoid fever surveillance in africa and the severe typhoid fever in africa programs contribute to the introduction of typhoid conjugate vaccines?
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821306/
https://www.ncbi.nlm.nih.gov/pubmed/31665772
http://dx.doi.org/10.1093/cid/ciz629
work_keys_str_mv AT jeonhyonjin howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT imjustin howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT haselbeckandrea howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT holmmarianne howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT rakotozandrindrainyraphael howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT bassiahiabdramanesoura howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT panznerursula howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT mogeniondarid howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT seohyejin howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT lunguyaoctavie howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT jacobsjan howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT okekeirukan howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT terferimekonnen howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT owusudaboellis howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT dougangordon howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT careymegan howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT steeleaduncan howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT kimjeromeh howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT clemensjohnd howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT andrewsjasonr howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT parkseeun howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT bakerstephen howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines
AT marksflorian howcanthetyphoidfeversurveillanceinafricaandtheseveretyphoidfeverinafricaprogramscontributetotheintroductionoftyphoidconjugatevaccines