Simultaneous precise editing of multiple genes in human cells

When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in insertions or deletions (indels), or by homology-directed repair (HDR), which allows precise nucleotide substitutions to be introduced if a donor oligo...

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Detalles Bibliográficos
Autores principales: Riesenberg, Stephan, Chintalapati, Manjusha, Macak, Dominik, Kanis, Philipp, Maricic, Tomislav, Pääbo, Svante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821318/
https://www.ncbi.nlm.nih.gov/pubmed/31392986
http://dx.doi.org/10.1093/nar/gkz669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821318/
https://www.ncbi.nlm.nih.gov/pubmed/31392986
http://dx.doi.org/10.1093/nar/gkz669

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