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Simultaneous precise editing of multiple genes in human cells
When double-strand breaks are introduced in a genome by CRISPR they are repaired either by non-homologous end joining (NHEJ), which often results in insertions or deletions (indels), or by homology-directed repair (HDR), which allows precise nucleotide substitutions to be introduced if a donor oligo...
Autores principales: | Riesenberg, Stephan, Chintalapati, Manjusha, Macak, Dominik, Kanis, Philipp, Maricic, Tomislav, Pääbo, Svante |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821318/ https://www.ncbi.nlm.nih.gov/pubmed/31392986 http://dx.doi.org/10.1093/nar/gkz669 |
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