Oxazinomycin arrests RNA polymerase at the polythymidine sequences

Oxazinomycin is a C-nucleoside antibiotic that is produced by Streptomyces hygroscopicus and closely resembles uridine. Here, we show that the oxazinomycin triphosphate is a good substrate for bacterial and eukaryotic RNA polymerases (RNAPs) and that a single incorporated oxazinomycin is rapidly ext...

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Detalles Bibliográficos
Autores principales: Prajapati, Ranjit K, Rosenqvist, Petja, Palmu, Kaisa, Mäkinen, Janne J, Malinen, Anssi M, Virta, Pasi, Metsä-Ketelä, Mikko, Belogurov, Georgiy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821320/
https://www.ncbi.nlm.nih.gov/pubmed/31495891
http://dx.doi.org/10.1093/nar/gkz782

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