Molecular basis of abasic site sensing in single-stranded DNA by the SRAP domain of E. coli yedK

HMCES and yedK were recently identified as sensors of abasic sites in ssDNA. In this study, we present multiple crystal structures captured in the apo-, nonspecific-substrate-binding, specific-substrate-binding, and product-binding states of yedK. In combination with biochemical data, we unveil the...

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Detalles Bibliográficos
Autores principales: Wang, Na, Bao, Hongyu, Chen, Liu, Liu, Yanhong, Li, Yue, Wu, Baixing, Huang, Hongda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821365/
https://www.ncbi.nlm.nih.gov/pubmed/31504793
http://dx.doi.org/10.1093/nar/gkz744

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