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Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats

The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear output – signal threat probability in male rats (Wright...

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Autores principales: Wright, Kristina M, Jhou, Thomas C, Pimpinelli, Daniel, McDannald, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821491/
https://www.ncbi.nlm.nih.gov/pubmed/31566567
http://dx.doi.org/10.7554/eLife.50054
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author Wright, Kristina M
Jhou, Thomas C
Pimpinelli, Daniel
McDannald, Michael A
author_facet Wright, Kristina M
Jhou, Thomas C
Pimpinelli, Daniel
McDannald, Michael A
author_sort Wright, Kristina M
collection PubMed
description The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear output – signal threat probability in male rats (Wright et al., 2019). Here, we scrutinize the activity vlPAG neurons that decrease firing to danger. One cue-inhibited population flipped danger activity from early inhibition to late excitation: a poor neural substrate for fear output, but a better substrate for threat timing. A second population showed differential firing with greatest inhibition to danger, less to uncertainty and no inhibition to safety. The pattern of differential firing reflected the pattern of fear output, and was observed throughout cue presentation. The results reveal an expected vlPAG signal for fear output in an unexpected, cue-inhibited population.
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spelling pubmed-68214912019-10-31 Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats Wright, Kristina M Jhou, Thomas C Pimpinelli, Daniel McDannald, Michael A eLife Neuroscience The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue – the presumed neural substrate for fear output – signal threat probability in male rats (Wright et al., 2019). Here, we scrutinize the activity vlPAG neurons that decrease firing to danger. One cue-inhibited population flipped danger activity from early inhibition to late excitation: a poor neural substrate for fear output, but a better substrate for threat timing. A second population showed differential firing with greatest inhibition to danger, less to uncertainty and no inhibition to safety. The pattern of differential firing reflected the pattern of fear output, and was observed throughout cue presentation. The results reveal an expected vlPAG signal for fear output in an unexpected, cue-inhibited population. eLife Sciences Publications, Ltd 2019-09-30 /pmc/articles/PMC6821491/ /pubmed/31566567 http://dx.doi.org/10.7554/eLife.50054 Text en © 2019, Wright et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Wright, Kristina M
Jhou, Thomas C
Pimpinelli, Daniel
McDannald, Michael A
Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title_full Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title_fullStr Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title_full_unstemmed Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title_short Cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
title_sort cue-inhibited ventrolateral periaqueductal gray neurons signal fear output and threat probability in male rats
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821491/
https://www.ncbi.nlm.nih.gov/pubmed/31566567
http://dx.doi.org/10.7554/eLife.50054
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