Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center of the interface of T cells activated by antigen-presenting cells. We have determined that it is compose...

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Detalles Bibliográficos
Autores principales: Clark, Danielle J, McMillan, Laura E, Tan, Sin Lih, Bellomo, Gaia, Massoue, Clementine, Thompson, Harry, Mykhaylechko, Lidiya, Alibhai, Dominic, Ruan, Xiongtao, Singleton, Kentner L, Du, Minna, Hedges, Alan, Schwartzberg, Pamela L, Verkade, Paul, Murphy, Robert F, Wülfing, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821493/
https://www.ncbi.nlm.nih.gov/pubmed/31663508
http://dx.doi.org/10.7554/eLife.45789

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