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Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation
Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell (HSC) compartment, while signaling pathway mutations, including KRAS activating mutations, a...
Autores principales: | Di Genua, Cristina, Norfo, Ruggiero, Rodriguez-Meira, Alba, Wen, Wei Xiong, Drissen, Roy, Booth, Christopher A.G., Povinelli, Benjamin, Repapi, Emmanouela, Gray, Nicki, Carrelha, Joana, Kettyle, Laura M., Jamieson, Lauren, Neo, Wen Hao, Thongjuea, Supat, Nerlov, Claus, Mead, Adam J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821613/ https://www.ncbi.nlm.nih.gov/pubmed/30975913 http://dx.doi.org/10.3324/haematol.2018.205351 |
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