The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT

Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplan...

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Autores principales: Bakhtiar, Shahrzad, Shadur, Bella, Stepensky, Polina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821686/
https://www.ncbi.nlm.nih.gov/pubmed/31709206
http://dx.doi.org/10.3389/fped.2019.00436
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author Bakhtiar, Shahrzad
Shadur, Bella
Stepensky, Polina
author_facet Bakhtiar, Shahrzad
Shadur, Bella
Stepensky, Polina
author_sort Bakhtiar, Shahrzad
collection PubMed
description Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature.
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spelling pubmed-68216862019-11-08 The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT Bakhtiar, Shahrzad Shadur, Bella Stepensky, Polina Front Pediatr Pediatrics Congenital disorders of the immune system affecting maturation and/or function of phagocytic leucocytes can result in severe infectious and inflammatory complications with high mortality and morbidity. Further complications include progression to MDS/AML in some cases. Allogeneic stem cell transplantation is the only curative treatment for most patients with these diseases. In this review, we provide a detailed update on indications and outcomes of alloHSCT for congenital neutrophil disorders, based on data from the available literature. Frontiers Media S.A. 2019-10-24 /pmc/articles/PMC6821686/ /pubmed/31709206 http://dx.doi.org/10.3389/fped.2019.00436 Text en Copyright © 2019 Bakhtiar, Shadur and Stepensky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Bakhtiar, Shahrzad
Shadur, Bella
Stepensky, Polina
The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title_full The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title_fullStr The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title_full_unstemmed The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title_short The Evidence for Allogeneic Hematopoietic Stem Cell Transplantation for Congenital Neutrophil Disorders: A Comprehensive Review by the Inborn Errors Working Party Group of the EBMT
title_sort evidence for allogeneic hematopoietic stem cell transplantation for congenital neutrophil disorders: a comprehensive review by the inborn errors working party group of the ebmt
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821686/
https://www.ncbi.nlm.nih.gov/pubmed/31709206
http://dx.doi.org/10.3389/fped.2019.00436
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