An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Mutations and variations in and around SCN5A, encoding the major cardiac sodium channel, influence impulse conduction and are associated with a broad spectrum of arrhythmia disorders. Here, we identify an evolutionary conserved regulatory cluster with super enhancer characteristics downstream of SCN...

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Detalles Bibliográficos
Autores principales: Man, Joyce C. K., Mohan, Rajiv A., Boogaard, Malou van den, Hilvering, Catharina R. E., Jenkins, Catherine, Wakker, Vincent, Bianchi, Valerio, Laat, Wouter de, Barnett, Phil, Boukens, Bastiaan J., Christoffels, Vincent M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821807/
https://www.ncbi.nlm.nih.gov/pubmed/31666509
http://dx.doi.org/10.1038/s41467-019-12856-5

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