Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

BACKGROUND: About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have treatment-resistant depression. METHODS: This Phase 3, double-blind, multicenter study enrolled adults with moderate-to-severe depression and n...

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Detalles Bibliográficos
Autores principales: Fedgchin, Maggie, Trivedi, Madhukar, Daly, Ella J, Melkote, Rama, Lane, Rosanne, Lim, Pilar, Vitagliano, Dawn, Blier, Pierre, Fava, Maurizio, Liebowitz, Michael, Ravindran, Arun, Gaillard, Raphael, Ameele, Hans Van Den, Preskorn, Sheldon, Manji, Husseini, Hough, David, Drevets, Wayne C, Singh, Jaskaran B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822141/
https://www.ncbi.nlm.nih.gov/pubmed/31290965
http://dx.doi.org/10.1093/ijnp/pyz039

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