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Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs

[Image: see text] Nucleoside analogues are among the most common medications given for the treatment of viral infections and cancers. The therapeutic effectiveness of nucleoside analogues can be dramatically improved by phosphorylation. The ProTide approach was developed using a phosphorylated nucle...

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Detalles Bibliográficos
Autores principales:	Xiang, Dao Feng, Bigley, Andrew N., Desormeaux, Emily, Narindoshvili, Tamari, Raushel, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822272/ https://www.ncbi.nlm.nih.gov/pubmed/31268686 http://dx.doi.org/10.1021/acs.biochem.9b00530

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