Cargando…

Enzyme-Catalyzed Kinetic Resolution of Chiral Precursors to Antiviral Prodrugs

[Image: see text] Nucleoside analogues are among the most common medications given for the treatment of viral infections and cancers. The therapeutic effectiveness of nucleoside analogues can be dramatically improved by phosphorylation. The ProTide approach was developed using a phosphorylated nucle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiang, Dao Feng, Bigley, Andrew N., Desormeaux, Emily, Narindoshvili, Tamari, Raushel, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822272/ https://www.ncbi.nlm.nih.gov/pubmed/31268686 http://dx.doi.org/10.1021/acs.biochem.9b00530

Ejemplares similares

Lipase-Catalyzed Kinetic Resolution of Aryltrimethylsilyl Chiral Alcohols
por: Palmeira, Dayvson J., et al.
Publicado: (2011)

Ketoreductase Catalyzed (Dynamic) Kinetic Resolution for Biomanufacturing of Chiral Chemicals
por: Huang, Chenming, et al.
Publicado: (2022)

Chiral isothiourea-catalyzed kinetic resolution of 4-hydroxy[2.2]paracyclophane
por: Weinzierl, David, et al.
Publicado: (2021)

Parallel kinetic resolution of aziridines via chiral phosphoric acid-catalyzed apparent hydrolytic ring-opening
por: Liu, Juan, et al.
Publicado: (2023)

Access to P-chiral sec- and tert-phosphine oxides enabled by Le-Phos-catalyzed asymmetric kinetic resolution
por: Qiu, Haile, et al.
Publicado: (2020)

EnzyKR: a chirality-aware deep learning model for predicting the outcomes of the hydrolase-catalyzed kinetic resolution
por: Ran, Xinchun, et al.
Publicado: (2023)

Rare‐Earth‐Metal‐Catalyzed Kinetic Resolution of Chiral Aminoalkenes via Hydroamination: The Effect of the Silyl Substituent of the Binaphtholate Ligand on Resolution Efficiency
por: Nguyen, Hiep N., et al.
Publicado: (2019)

Large-scale ruthenium- and enzyme-catalyzed dynamic kinetic resolution of (rac)-1-phenylethanol
por: Bogár, Krisztián, et al.
Publicado: (2007)

The Application of Transient-State Kinetic Isotope Effects to the Resolution of Mechanisms of Enzyme-Catalyzed Reactions
por: Fisher, Harvey F.
Publicado: (2013)

Functional Annotation and Structural Characterization of a Novel Lactonase Hydrolyzing d-Xylono-1,4-lactone-5-phosphate and l-Arabino-1,4-lactone-5-phosphate
por: Korczynska, Magdalena, et al.
Publicado: (2014)

The Unexplored Importance of Fleeting Chiral Intermediates in Enzyme-Catalyzed Reactions
por: Reetz, Manfred T., et al.
Publicado: (2021)

Intensification of Double Kinetic Resolution of Chiral Amines and Alcohols via Chemoselective Formation of a Carbonate–Enzyme Intermediate
por: Samsonowicz-Górski, Jan, et al.
Publicado: (2022)

Transaminase‐Catalyzed Racemization with Potential for Dynamic Kinetic Resolutions
por: Ruggieri, Federica, et al.
Publicado: (2018)

Advances in antiviral nucleoside analogues and their prodrugs
por: Seley-Radtke, Katherine, et al.
Publicado: (2018)

Imaging enzyme kinetics at atomic resolution
por: Spence, John, et al.
Publicado: (2016)

Hydrogen‐Bond‐Enabled Dynamic Kinetic Resolution of Axially Chiral Amides Mediated by a Chiral Counterion
por: Fugard, Alison J., et al.
Publicado: (2019)

Kinetic Resolution: A Powerful Tool for the Synthesis of Planar-Chiral Ferrocenes
por: Alba, Andrea-Nekane R., et al.
Publicado: (2009)

Practical and Scalable Kinetic Resolution of BINOLs Mediated by a Chiral Counterion
por: Jones, Benjamin A., et al.
Publicado: (2019)

Enantioselective preparation of mechanically planar chiral rotaxanes by kinetic resolution strategy
por: Imayoshi, Ayumi, et al.
Publicado: (2021)

Rhodium-catalyzed enantioselective C–H alkynylation of sulfoxides in diverse patterns: desymmetrization, kinetic resolution, and parallel kinetic resolution
por: Kong, Lingheng, et al.
Publicado: (2022)

Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
por: Denny, William A
Publicado: (2003)

Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
por: Yoneda, Naoki, et al.
Publicado: (2017)

Isothiourea‐Catalyzed Acylative Kinetic Resolution of Tertiary α‐Hydroxy Esters
por: Qu, Shen, et al.
Publicado: (2020)

Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols
por: Guo, Jia, et al.
Publicado: (2022)

Substrate Mediated Enzyme Prodrug Therapy
por: Fejerskov, Betina, et al.
Publicado: (2012)

Enzyme Models—From Catalysis to Prodrugs
por: Breijyeh, Zeinab, et al.
Publicado: (2021)

Structural Characterization and Function Determination of a Nonspecific Carboxylate Esterase from the Amidohydrolase Superfamily with a Promiscuous Ability To Hydrolyze Methylphosphonate Esters
por: Xiang, Dao Feng, et al.
Publicado: (2014)

Synthesis of Chiral Chalcone Derivatives Catalyzed by the Chiral Cinchona Alkaloid Squaramide
por: Xie, Dandan, et al.
Publicado: (2014)

Microbial cytosine deaminase is a programmable anticancer prodrug mediating enzyme: antibody, and gene directed enzyme prodrug therapy
por: El-Sayed, Ashraf S.A., et al.
Publicado: (2022)

Chirality recognition of winding vine-shaped heterobiaryls with molecular asymmetry. Kinetic and dynamic kinetic resolution by Shi’s asymmetric epoxidation
por: Maruhashi, Kazuki, et al.
Publicado: (2018)

Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs
por: Liu, Yingguo, et al.
Publicado: (2019)

Kinetic Modeling of a Consecutive Enzyme-Catalyzed Enantioselective Reaction in Supercritical Media
por: Gustavo, Michael Freitas, et al.
Publicado: (2020)

PDEPT: polymer-directed enzyme prodrug therapy
por: Satchi, R, et al.
Publicado: (2001)

Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles
por: Zhang, Lei, et al.
Publicado: (2019)

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals
por: Gollnest, Tristan, et al.
Publicado: (2015)

Tailored trisubstituted chiral Cp(x)Rh(III) catalysts for kinetic resolutions of phosphinic amides
por: Sun, Y., et al.
Publicado: (2018)

Recent Advances in Dynamic Kinetic Resolution by Chiral Bifunctional (Thio)urea- and Squaramide-Based Organocatalysts
por: Li, Pan, et al.
Publicado: (2016)

Dynamic parallel kinetic resolution of α-ferrocenyl cation initiated by chiral Brønsted acid catalyst
por: Toda, Yasunori, et al.
Publicado: (2021)

Manganese complex-catalyzed oxidation and oxidative kinetic resolution of secondary alcohols by hydrogen peroxide
por: Miao, Chengxia, et al.
Publicado: (2017)

Copper-catalyzed asymmetric hydrogenation of 2-substituted ketones via dynamic kinetic resolution
por: Zatolochnaya, Olga V., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dvfpf3pdt4bc7p2d4l9gm0lajt